RE: Non-physiological parameters at lowest OBJ
From: Justin Wilkins <jwilkins@uctgsh1.uct.ac.za>
Subject: RE: [NMusers] Non-physiological parameters at lowest OBJ
Date: 8/6/2003 6:15 AM
Hi to everyone,
Thanks for all the comments so far, they've been very helpful. I've
included the salient points of each scenario below:
Case 1: Case 2:
OBJ 1761.159 1983.937
KA: 0.053 (4%) 0.500 (28%)
V: 3.10 (12%) 37.9 (5%)
CL: 2.29 (6%) 2.13 (5%)
ALAG: 1.49 (4%) 1.13 (11%)
ADD error: 0.370 (29%) 0.336 (19%)
EXP error: 0.150 (9%) 0.186 (14%)
Figures in brackets represent residual standard error on each term. The
data is rich (n=45, 2 occasions), and the analysis is using
ADVAN2/TRANS2 with FOCE without interaction. The drug has a long
half-life. The only difference between case 1 and case 2 are that case 2
has a lower constraint of 7 applied to the CL initial estimate.
Justin