RE: OMEGA HAS A NONZERO BLOCK

From:"Kowalski, Ken" Subject:RE: [NMusers] OMEGA HAS A NONZERO BLOCK Date:Mon, 7 Oct 2002 15:44:14 -0400 Mats, I agree with you. Of course, it may be difficult to find an estimate of a correlation (so many pop PK/PD results don't report this estimate and many assume a diagonal Omega anyway). Moreover, if one has an estimate I would also like to look at the precision of this estimate before I fixed it. If its not very precisely estimated then I would want to take this imprecision into account as it may be such a weak prior that it is of little help anyway. In any event, this is the data I'm looking for to support the prior. Ken