Re: OMEGA HAS A NONZERO BLOCK

From:Nick Holford Subject:Re: [NMusers] OMEGA HAS A NONZERO BLOCK Date: Wed, 02 Oct 2002 15:41:24 +1200 Steve, This can be caused by the minor differences that occur when converting between the text representation of a number (in the NM-TRAN control stream) and the internal representation of the corresponding double precision value. If you "round down" the last digit of the off diagonal elements of $OMEGA you may find that NONMEM will then accept it e.g. $OMEGA BLOCK(4) ;BSV 0.329 0.204 0.272 0.160 -0.216 0.774 0.00817 0.0047 0.00461 0.000204 I find this problem occurs quite often if I take the OMEGA estimates of a NONMEM run from the NONMEM listing and put them into an NM-TRAN control stream and is usually fixed with the "round down" kludge. Nick Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/