RE: OMEGA HAS A NONZERO BLOCK

From:Pascal Girard Subject:RE: [NMusers] OMEGA HAS A NONZERO BLOCK Date:Wed, 2 Oct 2002 00:25:42 -0700 Hi Steve, I often encountered the problem when I want to resample OMEGAs from MVN distribution using a non-diagonal final OMEGA. I fixed it definitively by writing my own INFN subroutine which outputs final OMEGA in an ASCII file, with more digits than the one provided by NONMEM output. By the way this is really not rocket science. It would be much more efficient to have an option in NONMEM that outputs all NONMEM estimates, with sufficient precisions, (Objective functions, THETAs, OMEGAs and SIGMAs, SE, COV matrix ..., indexed by the PROB #) in an ASCII, EXCEL compatible, file. Software like SAS statistical procedures or Splus functions offer this functionality. This would be a kind of sophisticated Model Specification File, but in ASCII, rather than binary coding. (Hope Stuart is listening -:) All my best, Pascal Girard Tel/Fax +33 (0)437 37 80 29