Dear all
I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
____________________
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krogshjvej 53 A
DK-2880 Bagsvrd
Denmark
+45 4442 4960 (direct)
+45 3079 4960 (mobile)
tkt
www.novonordisk.com
Changing possibilities in haemophilia
Did you know that 75% of people with haemophilia live in developing countries, and receive neither proper diagnosis nor adequate care and treatment? This reduces life expectancy down to just the teenage years. The Novo Nordisk Haemophilia Foundation supports 22 projects in the developing world to improve haemophilia care and treatment. Learn more http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp
This e-mail (including any attachments) is intended for the addressee(s) stated above only and may contain confidential information protected by law. You are hereby notified that any unauthorized reading, disclosure, copying or distribution of this e-mail or use of information contained herein is strictly prohibited and may violate rights to proprietary information. If you are not an intended recipient, please return this e-mail to the sender and delete it immediately hereafter. Thank you.
Resetting af single compartment
Thomas,
Two solutions (their smart scale is up to you to judge ;-):
1 - rewrite the model so you don't need the changepoint (best approach IMHO)
2 - I guess you could switch the model to a different differential equation instead
e.g.
CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
DADT(3) = SLCT*CHNG
DADT(4) = (1-SLCT)*CHNG
But I have not tested that approach. I guess it should work.
Best regards,
Jeroen
Jeroen Elassaiss-Schaap, PhD
Modeling & Simulation Expert
Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
Early Clinical Research and Experimental Medicine
Schering-Plough Research Institute
T: +31 41266 9320
_____
Quoted reply history
From: owner-nmusers
On Behalf Of TKT (Thomas Klitgaard)
Sent: Thursday, 23 April, 2009 15:20
To: nmusers
Subject: [NMusers] Resetting af single compartment
Dear all
I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
____________________
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krogshjvej 53 A
DK-2880 Bagsvrd
Denmark
+45 4442 4960 (direct)
+45 3079 4960 (mobile)
tkt
www.novonordisk.com
Changing possibilities in haemophilia
Did you know that 75% of people with haemophilia live in developing countries, and receive neither proper diagnosis nor adequate care and treatment? This reduces life expectancy down to just the teenage years. The Novo Nordisk Haemophilia Foundation supports 22 projects in the developing world to improve haemophilia care and treatment. Learn more http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp
This e-mail (including any attachments) is intended for the addressee(s) stated above only and may contain confidential information protected by law. You are hereby notified that any unauthorized reading, disclosure, copying or distribution of this e-mail or use of information contained herein is strictly prohibited and may violate rights to proprietary information. If you are not an intended recipient, please return this e-mail to the sender and delete it immediately hereafter. Thank you.
This message and any attachments are solely for the intended recipient. If you are not the intended recipient, disclosure, copying, use or distribution of the information included in this message is prohibited --- Please immediately and permanently delete.
Dear all
I need to reset a single compartment in a model of several cmts, without
resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
____________________
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krogshøjvej 53 A
DK-2880 Bagsværd
Denmark
+45 4442 4960 (direct)
+45 3079 4960 (mobile)
[email protected]
www.novonordisk.com
Changing possibilities in haemophilia
Did you know that 75% of people with haemophilia live in developing countries,
and receive neither proper diagnosis nor adequate care and treatment? This
reduces life expectancy down to just the teenage years. The Novo Nordisk
Haemophilia Foundation supports 22 projects in the developing world to improve
haemophilia care and treatment. Learn more
http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp
This e-mail (including any attachments) is intended for the addressee(s) stated
above only and may contain confidential information protected by law. You are
hereby notified that any unauthorized reading, disclosure, copying or
distribution of this e-mail or use of information contained herein is strictly
prohibited and may violate rights to proprietary information. If you are not an
intended recipient, please return this e-mail to the sender and delete it
immediately hereafter. Thank you.
Thomas,
Two solutions (their smart scale is up to you to judge ;-):
1 - rewrite the model so you don't need the changepoint (best approach IMHO)
2 - I guess you could switch the model to a different differential equation
instead
e.g.
CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
DADT(3) = SLCT*CHNG
DADT(4) = (1-SLCT)*CHNG
But I have not tested that approach. I guess it should work.
Best regards,
Jeroen
Jeroen Elassaiss-Schaap, PhD
Modeling & Simulation Expert
Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
Early Clinical Research and Experimental Medicine
Schering-Plough Research Institute
T: +31 41266 9320
_____
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of TKT (Thomas Klitgaard)
Sent: Thursday, 23 April, 2009 15:20
To: [email protected]
Subject: [NMusers] Resetting af single compartment
Dear all
I need to reset a single compartment in a model of several cmts, without
resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
____________________
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krogshøjvej 53 A
DK-2880 Bagsværd
Denmark
+45 4442 4960 (direct)
+45 3079 4960 (mobile)
[email protected]
www.novonordisk.com
Changing possibilities in haemophilia
Did you know that 75% of people with haemophilia live in developing countries,
and receive neither proper diagnosis nor adequate care and treatment? This
reduces life expectancy down to just the teenage years. The Novo Nordisk
Haemophilia Foundation supports 22 projects in the developing world to improve
haemophilia care and treatment. Learn more
http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp
This e-mail (including any attachments) is intended for the addressee(s) stated
above only and may contain confidential information protected by law. You are
hereby notified that any unauthorized reading, disclosure, copying or
distribution of this e-mail or use of information contained herein is strictly
prohibited and may violate rights to proprietary information. If you are not an
intended recipient, please return this e-mail to the sender and delete it
immediately hereafter. Thank you.
This message and any attachments are solely for the intended recipient. If you
are not the intended recipient, disclosure, copying, use or distribution of the
information included in this message is prohibited --- Please immediately and
permanently delete.
From the NM help for CMT data item:
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
So my guess is that
EVID CMT
2 -3
2 3
Should reset this particular compartment 3 (although I never tried it)
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Elassaiss - Schaap, J. (Jeroen) wrote:
> Thomas, Two solutions (their smart scale is up to you to judge ;-): 1 - rewrite the model so you don't need the changepoint (best approach IMHO) 2 - I guess you could switch the model to a different differential equation instead
>
> e.g.
> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> DADT(3) = SLCT*CHNG
> DADT(4) = (1-SLCT)*CHNG
> But I have not tested that approach. I guess it should work.
>
> Best regards,
>
> Jeroen
>
> *Jeroen Elassaiss-Schaap, PhD*
> Modeling & Simulation Expert
> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> Early Clinical Research and Experimental Medicine
> Schering-Plough Research Institute
> T: +31 41266 9320
>
> ------------------------------------------------------------------------
>
> *From:* [email protected] [ mailto: [email protected] ] *On Behalf Of *TKT (Thomas Klitgaard)
>
> *Sent:* Thursday, 23 April, 2009 15:20
> *To:* [email protected]
> *Subject:* [NMusers] Resetting af single compartment
>
> Dear all
>
> I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
>
> subject (which EVID=4 would do). Is there a *smart* way to do this?
>
> Thanks,
>
> Thomas
>
> ____________________
>
> *Thomas Klitgaard
> *Principal Scientist
> Biomodelling
>
> Novo Nordisk A/S
> Krogshøjvej 53 A
> DK-2880 Bagsværd
> Denmark
> +45 4442 4960 (direct)
> +45 3079 4960 (mobile)
> [email protected]
> _www.novonordisk.com_
>
> *Changing **possibilities in haemophilia
>
> *Did you know that 75% of people with haemophilia live in developing countries, and receive neither proper diagnosis nor adequate care and treatment? This reduces life expectancy down to just the teenage years. The Novo Nordisk Haemophilia Foundation supports 22 projects in the developing world to improve haemophilia care and treatment. _Learn more _ < http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp >
>
> This e-mail (including any attachments) is intended for the addressee(s) stated above only and may contain confidential information protected by law. You are hereby notified that any unauthorized reading, disclosure, copying or distribution of this e-mail or use of information contained herein is strictly prohibited and may violate rights to proprietary information. If you are not an intended recipient, please return this e-mail to the sender and delete it immediately hereafter. Thank you.
>
> ------------------------------------------------------------------------
>
> This message and any attachments are solely for the intended recipient. If you are not the intended recipient, disclosure, copying, use or distribution of the information included in this message is prohibited --- Please immediately and permanently delete.
>
>
I have not tried it either, but, I think this would not reset the amounts in
these compartments. I believe it would retain the value when turned off until
turned back on.
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Leonid Gibiansky
Sent: Thursday, April 23, 2009 11:40 AM
To: Elassaiss - Schaap, J. (Jeroen)
Cc: [email protected]; TKT (Thomas Klitgaard)
Subject: Re: [NMusers] Resetting af single compartment
From the NM help for CMT data item:
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
So my guess is that
EVID CMT
2 -3
2 3
Should reset this particular compartment 3 (although I never tried it)
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Elassaiss - Schaap, J. (Jeroen) wrote:
>
> Thomas,
>
> Two solutions (their smart scale is up to you to judge ;-):
>
> 1 - rewrite the model so you don't need the changepoint (best approach IMHO)
>
> 2 - I guess you could switch the model to a different differential
> equation instead
> e.g.
> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> DADT(3) = SLCT*CHNG
> DADT(4) = (1-SLCT)*CHNG
> But I have not tested that approach. I guess it should work.
>
> Best regards,
> Jeroen
>
> *Jeroen Elassaiss-Schaap, PhD*
> Modeling & Simulation Expert
> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> Early Clinical Research and Experimental Medicine
> Schering-Plough Research Institute
> T: +31 41266 9320
>
>
>
> ------------------------------------------------------------------------
> *From:* [email protected]
> [mailto:[email protected]] *On Behalf Of *TKT (Thomas Klitgaard)
> *Sent:* Thursday, 23 April, 2009 15:20
> *To:* [email protected]
> *Subject:* [NMusers] Resetting af single compartment
>
> Dear all
>
> I need to reset a single compartment in a model of several cmts, without
> resetting the whole system for the
> subject (which EVID=4 would do). Is there a *smart* way to do this?
>
> Thanks,
> Thomas
>
>
> ____________________
>
> *Thomas Klitgaard
> *Principal Scientist
> Biomodelling
>
> Novo Nordisk A/S
> Krogshøjvej 53 A
> DK-2880 Bagsværd
> Denmark
> +45 4442 4960 (direct)
> +45 3079 4960 (mobile)
> [email protected]
> _www.novonordisk.com_
>
> *Changing **possibilities in haemophilia
> *Did you know that 75% of people with haemophilia live in developing
> countries, and receive neither proper diagnosis nor adequate care and
> treatment? This reduces life expectancy down to just the teenage years.
> The Novo Nordisk Haemophilia Foundation supports 22 projects in the
> developing world to improve haemophilia care and treatment. _Learn more
> _
> http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp
>
> This e-mail (including any attachments) is intended for the addressee(s)
> stated above only and may contain confidential information protected by
> law. You are hereby notified that any unauthorized reading, disclosure,
> copying or distribution of this e-mail or use of information contained
> herein is strictly prohibited and may violate rights to proprietary
> information. If you are not an intended recipient, please return this
> e-mail to the sender and delete it immediately hereafter. Thank you.
>
>
> ------------------------------------------------------------------------
> This message and any attachments are solely for the intended recipient.
> If you are not the intended recipient, disclosure, copying, use or
> distribution of the information included in this message is prohibited
> --- Please immediately and permanently delete.
>
Dear Thomas,
Compartments can be turned on and off by specifying extra events (EVID=2) in
the data set. To turn off CMT N use CMT column equal to N, to turn it on
use N in CMT column.
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
Dept of Pharmaceutical Biosciences
Uppsala University
Box 591
751 24 Uppsala Sweden
phone: +46 18 4714105
fax: +46 18 471 4003
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of TKT (Thomas Klitgaard)
Sent: Thursday, April 23, 2009 3:20 PM
To: [email protected]
Subject: [NMusers] Resetting af single compartment
Dear all
I need to reset a single compartment in a model of several cmts, without
resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
____________________
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krogshøjvej 53 A
DK-2880 Bagsværd
Denmark
+45 4442 4960 (direct)
+45 3079 4960 (mobile)
[email protected]
www.novonordisk.com
Changing possibilities in haemophilia
Did you know that 75% of people with haemophilia live in developing
countries, and receive neither proper diagnosis nor adequate care and
treatment? This reduces life expectancy down to just the teenage years. The
Novo Nordisk Haemophilia Foundation supports 22 projects in the developing
world to improve haemophilia care and treatment. Learn
http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibili
tiesActivities/HaemophiliaTreatment2.asp more
This e-mail (including any attachments) is intended for the addressee(s)
stated above only and may contain confidential information protected by law.
You are hereby notified that any unauthorized reading, disclosure, copying
or distribution of this e-mail or use of information contained herein is
strictly prohibited and may violate rights to proprietary information. If
you are not an intended recipient, please return this e-mail to the sender
and delete it immediately hereafter. Thank you.
Hi,
I can tell you from real experience that CMT=negative resets that compartment to zero and turns the CMT off i.e. it will not accumulate anything. A subsequent CMT=positive will turn the CMT on i.e. it will then start to accumulate. This is a very helpful feature in NONMEM for those interested in using intermittent collections from a PK CMT e.g. using urine.
Nick
Bachman, William wrote:
> I have not tried it either, but, I think this would not reset the amounts in these compartments. I believe it would retain the value when turned off until turned back on.
>
Quoted reply history
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Leonid Gibiansky
> Sent: Thursday, April 23, 2009 11:40 AM
> To: Elassaiss - Schaap, J. (Jeroen)
> Cc: [email protected]; TKT (Thomas Klitgaard)
> Subject: Re: [NMusers] Resetting af single compartment
>
> From the NM help for CMT data item:
>
> Other-Type Event:
> A positive value of CMT specifies a compartment to be turned on.
> A negative value of CMT specifies a compartment to be turned off.
>
> So my guess is that
>
> EVID CMT
> 2 -3
> 2 3
>
> Should reset this particular compartment 3 (although I never tried it)
> Leonid
>
> --------------------------------------
> Leonid Gibiansky, Ph.D.
> President, QuantPharm LLC
> web: www.quantpharm.com
> e-mail: LGibiansky at quantpharm.com
> tel: (301) 767 5566
>
> Elassaiss - Schaap, J. (Jeroen) wrote:
>
> > Thomas, Two solutions (their smart scale is up to you to judge ;-): 1 - rewrite the model so you don't need the changepoint (best approach IMHO) 2 - I guess you could switch the model to a different differential equation instead
> >
> > e.g.
> > CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> > DADT(3) = SLCT*CHNG
> > DADT(4) = (1-SLCT)*CHNG
> > But I have not tested that approach. I guess it should work.
> >
> > Best regards,
> >
> > Jeroen
> >
> > *Jeroen Elassaiss-Schaap, PhD*
> > Modeling & Simulation Expert
> > Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> > Early Clinical Research and Experimental Medicine
> > Schering-Plough Research Institute
> > T: +31 41266 9320
> >
> > ------------------------------------------------------------------------
> >
> > *From:* [email protected] [ mailto: [email protected] ] *On Behalf Of *TKT (Thomas Klitgaard)
> >
> > *Sent:* Thursday, 23 April, 2009 15:20
> > *To:* [email protected]
> > *Subject:* [NMusers] Resetting af single compartment
> >
> > Dear all
> >
> > I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
> >
> > subject (which EVID=4 would do). Is there a *smart* way to do this?
> >
> > Thanks,
> >
> > Thomas
> >
> > ____________________
> >
> > *Thomas Klitgaard
> > *Principal Scientist
> > Biomodelling
> >
> > Novo Nordisk A/S
> > Krogshøjvej 53 A
> > DK-2880 Bagsværd
> > Denmark
> > +45 4442 4960 (direct)
> > +45 3079 4960 (mobile)
> > [email protected]
> > _www.novonordisk.com_
> >
> > *Changing **possibilities in haemophilia
> >
> > *Did you know that 75% of people with haemophilia live in developing countries, and receive neither proper diagnosis nor adequate care and treatment? This reduces life expectancy down to just the teenage years. The Novo Nordisk Haemophilia Foundation supports 22 projects in the developing world to improve haemophilia care and treatment. _Learn more _ < http://www.novonordisk.com/about_us/improving_haemophilia/ChangingPossibilitiesActivities/HaemophiliaTreatment2.asp >
> >
> > This e-mail (including any attachments) is intended for the addressee(s) stated above only and may contain confidential information protected by law. You are hereby notified that any unauthorized reading, disclosure, copying or distribution of this e-mail or use of information contained herein is strictly prohibited and may violate rights to proprietary information. If you are not an intended recipient, please return this e-mail to the sender and delete it immediately hereafter. Thank you.
> >
> > ------------------------------------------------------------------------
> >
> > This message and any attachments are solely for the intended recipient. If you are not the intended recipient, disclosure, copying, use or distribution of the information included in this message is prohibited --- Please immediately and permanently delete.
> >
> > ------------------------------------------------------------------------
>
>