RE: Resetting af single compartment
Thomas,
Two solutions (their smart scale is up to you to judge ;-):
1 - rewrite the model so you don't need the changepoint (best approach IMHO)
2 - I guess you could switch the model to a different differential equation instead
e.g.
CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
DADT(3) = SLCT*CHNG
DADT(4) = (1-SLCT)*CHNG
But I have not tested that approach. I guess it should work.
Best regards,
Jeroen
Jeroen Elassaiss-Schaap, PhD
Modeling & Simulation Expert
Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
Early Clinical Research and Experimental Medicine
Schering-Plough Research Institute
T: +31 41266 9320
_____
Quoted reply history
From: owner-nmusers
On Behalf Of TKT (Thomas Klitgaard)
Sent: Thursday, 23 April, 2009 15:20
To: nmusers
Subject: [NMusers] Resetting af single compartment
Dear all
I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
____________________
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krogshjvej 53 A
DK-2880 Bagsvrd
Denmark
+45 4442 4960 (direct)
+45 3079 4960 (mobile)
tkt
www.novonordisk.com
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