Re: Resetting af single compartment
Hi,
I can tell you from real experience that CMT=negative resets that compartment to zero and turns the CMT off i.e. it will not accumulate anything. A subsequent CMT=positive will turn the CMT on i.e. it will then start to accumulate. This is a very helpful feature in NONMEM for those interested in using intermittent collections from a PK CMT e.g. using urine.
Nick
Bachman, William wrote:
> I have not tried it either, but, I think this would not reset the amounts in these compartments. I believe it would retain the value when turned off until turned back on.
>
Quoted reply history
> -----Original Message-----
> From: [email protected] [mailto:[email protected]] On
> Behalf Of Leonid Gibiansky
> Sent: Thursday, April 23, 2009 11:40 AM
> To: Elassaiss - Schaap, J. (Jeroen)
> Cc: [email protected]; TKT (Thomas Klitgaard)
> Subject: Re: [NMusers] Resetting af single compartment
>
> From the NM help for CMT data item:
>
> Other-Type Event:
> A positive value of CMT specifies a compartment to be turned on.
> A negative value of CMT specifies a compartment to be turned off.
>
> So my guess is that
>
> EVID CMT
> 2 -3
> 2 3
>
> Should reset this particular compartment 3 (although I never tried it)
> Leonid
>
> --------------------------------------
> Leonid Gibiansky, Ph.D.
> President, QuantPharm LLC
> web: www.quantpharm.com
> e-mail: LGibiansky at quantpharm.com
> tel: (301) 767 5566
>
> Elassaiss - Schaap, J. (Jeroen) wrote:
>
> > Thomas, Two solutions (their smart scale is up to you to judge ;-): 1 - rewrite the model so you don't need the changepoint (best approach IMHO) 2 - I guess you could switch the model to a different differential equation instead
> >
> > e.g.
> > CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> > DADT(3) = SLCT*CHNG
> > DADT(4) = (1-SLCT)*CHNG
> > But I have not tested that approach. I guess it should work.
> >
> > Best regards,
> >
> > Jeroen
> >
> > *Jeroen Elassaiss-Schaap, PhD*
> > Modeling & Simulation Expert
> > Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> > Early Clinical Research and Experimental Medicine
> > Schering-Plough Research Institute
> > T: +31 41266 9320
> >
> > ------------------------------------------------------------------------
> >
> > *From:* [email protected] [ mailto: [email protected] ] *On Behalf Of *TKT (Thomas Klitgaard)
> >
> > *Sent:* Thursday, 23 April, 2009 15:20
> > *To:* [email protected]
> > *Subject:* [NMusers] Resetting af single compartment
> >
> > Dear all
> >
> > I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
> >
> > subject (which EVID=4 would do). Is there a *smart* way to do this?
> >
> > Thanks,
> >
> > Thomas
> >
> > ____________________
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