FW: Sensitive analysis
Sorry to join the conversation late but an alternative would be Phoenix
WinNonlin which can do this type of sensitivity analysis quite easily.
Simply append copies of the dataset for each scenario (to set sampling times
for each subject) and set the parameters for each scenario. A simulation will
then produce the predicted values for each case.
These can then be passed to the NCA tool in WinNonlin can be used to get Cmax
and AUC (which are sensitive to sampling times) and you can build a nice table
of the results. All within one software package and the workflow can be easily
exported as a template for re-use on other projects, or to share with
colleagues.
Best regards,
Simon.
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Quoted reply history
-----Original Message-----
From: [email protected]<mailto:[email protected]>
[mailto:[email protected]] On Behalf Of
[email protected]<mailto:[email protected]>
Sent: Sunday, February 19, 2012 5:55 PM
To: Norman Z
Cc: Denney, William S.; Standing Joseph (GREAT ORMOND STREET HOSPITAL FOR
CHILDREN NHS TRUST); [email protected]<mailto:[email protected]>
Subject: Re: [NMusers] Sensitive analysis
It seems to me that you have (at least) these two options:
- create a dense series of time points as a dummy data set for NONMEM, fix the
parameters, and write the predicted values into an output table (one per
parameter set)
- implement the model in Berkeley Madonna and export a table of predicted
values for the sets of parameters
For both cases I would calculate the AUC from the output table in R (or any
other suitable programming language).
Btw, a tool such as Pirana converts nonmem DES into BM code for you.
Andreas
-----
Andreas Krause, PhD
Director, Lead Scientist Modeling and Simulation Dept. of Clinical Pharmacology
Actelion Pharmaceuticals Ltd / Gewerbestrasse 16 / CH-4123 Allschwil /
Switzerland Phone +41 61 565 6891 / Email
[email protected]<mailto:[email protected]>
[email protected]<mailto:[email protected]>
wrote: -----
To: "Denney, William S."
<[email protected]<mailto:[email protected]>>, "Standing
Joseph (GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS TRUST)"
<[email protected]<mailto:[email protected]>>
From: Norman Z <[email protected]<mailto:[email protected]>>
Sent by: [email protected]<mailto:[email protected]>
Date: 2012-02-19 18:16
Cc: [email protected]<mailto:[email protected]>
Subject: Re: [NMusers] Sensitive analysis
Hi Bill and Joe,
Thank you very much for your suggestions.
What I am asking is "How sensitive is the simulated PK profiles (summerized by
AUC or Cmax) to changes in parameter y?".
So instead of looking at the OFV change with different parameters, I want to
summarize the result of the sensitive analysis. My goal is to obtain the AUC
and Cmax for the predicted PK profiles (the model have multiple compartments,
and I need to extract the AUC and Cmax for several compartments) with different
parameter values.
Does bootstrap or LLP in PsN out put all the intermediate simulation results?
Kind regards,
Norman
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