RE: Sensitive analysis
Norman,
Have a look at log-likelihood profiling in PsN. LLP documentation is on the
PsN website - I don't think it quite does what you want (it will look for
parameter values that give significant OFV changes rather than changing
parameters by certain proportions).
Best wishes,
Joe
Joseph F Standing
MRC Fellow, UCL Institute of Child Health
Antimicrobial Pharmacist, Great Ormond Street Hospital
Honorary Lecturer, UCL School of Pharmacy
Tel: +44(0)207 905 2370
Mobile: +44(0)7970 572435
Quoted reply history
________________________________
From: [email protected] [[email protected]] On Behalf Of
Norman Z [[email protected]]
Sent: 19 February 2012 02:16
To: [email protected]
Subject: [NMusers] Sensitive analysis
Hello everyone,
I am doing some sensitive analysis for the final model parameters, where I want
to increase/decrease the parameter estimation by 10% and look at its impact on
the model prediction.
My model is built in NONMEM 7. And I have WFN and PsN installed. I wonder if
anybody could suggest how to automatic carry out sensitive analysis. Is PsN or
WFN capable of doing so? Of course, the last resort would be to manually change
the parameters and run the model.
Thanks for your help.
Norman
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