RE: Sensitive analysis

From: Joseph Standing Date: February 19, 2012 technical Source: mail-archive.com
Norman, Have a look at log-likelihood profiling in PsN. LLP documentation is on the PsN website - I don't think it quite does what you want (it will look for parameter values that give significant OFV changes rather than changing parameters by certain proportions). Best wishes, Joe Joseph F Standing MRC Fellow, UCL Institute of Child Health Antimicrobial Pharmacist, Great Ormond Street Hospital Honorary Lecturer, UCL School of Pharmacy Tel: +44(0)207 905 2370 Mobile: +44(0)7970 572435
Quoted reply history
________________________________ From: [email protected] [[email protected]] On Behalf Of Norman Z [[email protected]] Sent: 19 February 2012 02:16 To: [email protected] Subject: [NMusers] Sensitive analysis Hello everyone, I am doing some sensitive analysis for the final model parameters, where I want to increase/decrease the parameter estimation by 10% and look at its impact on the model prediction. My model is built in NONMEM 7. And I have WFN and PsN installed. I wonder if anybody could suggest how to automatic carry out sensitive analysis. Is PsN or WFN capable of doing so? Of course, the last resort would be to manually change the parameters and run the model. Thanks for your help. Norman ******************************************************************************************************************** This message may contain confidential information. If you are not the intended recipient please inform the sender that you have received the message in error before deleting it. Please do not disclose, copy or distribute information in this e-mail or take any action in reliance on its contents: to do so is strictly prohibited and may be unlawful. Thank you for your co-operation. NHSmail is the secure email and directory service available for all NHS staff in England and Scotland NHSmail is approved for exchanging patient data and other sensitive information with NHSmail and GSi recipients NHSmail provides an email address for your career in the NHS and can be accessed anywhere For more information and to find out how you can switch, visit www.connectingforhealth.nhs.uk/nhsmail ********************************************************************************************************************
Feb 19, 2012 Norman Z Sensitive analysis
Feb 19, 2012 Bill Denney Re: Sensitive analysis
Feb 19, 2012 Joseph Standing RE: Sensitive analysis
Feb 19, 2012 Andreas . Krause Re: Sensitive analysis
Feb 19, 2012 Jakob Ribbing Re: Sensitive analysis
Feb 20, 2012 Nick Holford Re: Sensitive analysis
Feb 20, 2012 Joanna Lewis Re: Sensitive analysis
Feb 20, 2012 Norman Z Re: Sensitive analysis
Feb 24, 2012 Simon Davis FW: Sensitive analysis