Re: Sensitive analysis
Norman,
I am intrigued by your question because I cannot think of any good reason to want to understand this 'sensitivity'.
Note for AUC the 'sensitivity' is trivial to calculate because it is inversely proportional to CL (and proportional to F if you have F in our model).
Can you give me some idea what you want to do with this 'sensitivity'?
Best wishes,
Nick
Quoted reply history
On 20/02/2012 1:16 a.m., Norman Z wrote:
> Hi Bill and Joe,
> Thank you very much for your suggestions.
>
> What I am asking is "How sensitive is the simulated PK profiles (summerized by AUC or Cmax) to changes in parameter y?". So instead of looking at the OFV change with different parameters, I want to summarize the result of the sensitive analysis. My goal is to obtain the AUC and Cmax for the predicted PK profiles (the model have multiple compartments, and I need to extract the AUC and Cmax for several compartments) with different parameter values. Does bootstrap or LLP in PsN out put all the intermediate simulation results?
>
> Kind regards,
> Norman
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