Re: Sensitive analysis
Hi Norman,
With what you're asking, is the real question, "How sensitive is parameter x to
changes in parameter y?"
If so, the best method would probably be bootstrapping. In PsN, that can be
done with the bootstrap command. An alternate could be likelihood profiling
(llp in PsN), though the summary of the changes in the "y" parameter would have
to be done manually as far as I know with that.
Thanks,
Bill
Quoted reply history
On Feb 18, 2012, at 6:46 PM, "Norman Z" <[email protected]> wrote:
> Hello everyone,
>
> I am doing some sensitive analysis for the final model parameters, where I
> want to increase/decrease the parameter estimation by 10% and look at its
> impact on the model prediction.
> My model is built in NONMEM 7. And I have WFN and PsN installed. I wonder if
> anybody could suggest how to automatic carry out sensitive analysis. Is PsN
> or WFN capable of doing so? Of course, the last resort would be to manually
> change the parameters and run the model.
>
> Thanks for your help.
>
> Norman