Re: Sensitive analysis

It seems to me that you have (at least) these two options: - create a dense series of time points as a dummy data set for NONMEM, fix the parameters, and write the predicted values into an output table (one per parameter set) - implement the model in Berkeley Madonna and export a table of predicted values for the sets of parameters For both cases I would calculate the AUC from the output table in R (or any other suitable programming language). Btw, a tool such as Pirana converts nonmem DES into BM code for you. Andreas ----- Andreas Krause, PhD Director, Lead Scientist Modeling and Simulation Dept. of Clinical Pharmacology Actelion Pharmaceuticals Ltd / Gewerbestrasse 16 / CH-4123 Allschwil / Switzerland Phone +41 61 565 6891 / Email [email protected] [email protected] wrote: ----- To: "Denney, William S." <[email protected]>, "Standing Joseph (GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS TRUST)" <[email protected]> From: Norman Z <[email protected]> Sent by: [email protected] Date: 2012-02-19 18:16 Cc: [email protected] Subject: Re: [NMusers] Sensitive analysis Hi Bill and Joe, Thank you very much for your suggestions. What I am asking is "How sensitive is the simulated PK profiles (summerized by AUC or Cmax) to changes in parameter y?". So instead of looking at the OFV change with different parameters, I want to summarize the result of the sensitive analysis. My goal is to obtain the AUC and Cmax for the predicted PK profiles (the model have multiple compartments, and I need to extract the AUC and Cmax for several compartments) with different parameter values. Does bootstrap or LLP in PsN out put all the intermediate simulation results? Kind regards, Norman The information of this email and in any file transmitted with it is strictly confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, any copying, distribution or any other use of this email is prohibited and may be unlawful. In such case, you should please notify the sender immediately and destroy this email. The content of this email is not legally binding unless confirmed by letter. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorised to state them to be the views of the sender's company. For further information about Actelion please see our website at http://www.actelion.com