Re: Interpreting IOV

From: jeffrey.a.wald@gsk.com Subject: Re: [NMusers] Interpreting IOV Date: Fri, 16 Sep 2005 10:25:47 -0400 Hi Peter - An important piece of information that was left out was whether Vss was also varying between occasions. Depending on the PK profile of your drug, sampling schedule, infusion duration*, etc you may have difficulty resolving V1 and V2, but still have the same Vss. What is the correlation of the V1 V2 estimates? Have you tried parameterizing the model with IOV on Vss? Jeff *i.e., all iv administrations are 'infusions', but not all PK studies will resolve a short duration infusion of say 30 sec or less :) _______________________________________________________