Interpreting IOV

From: "Bonate, Peter" Peter.Bonate@genzyme.com Subject: [NMusers] Interpreting IOV Date: Thu, 15 Sep 2005 08:36:41 -0400 Hi, everyone. I am having trouble intepreting something and I was hoping the group would help. I am modeling an IV drug given on multiple occasions. The drug is consistent with a 2-compartment model. When I added IOV to all the model parameters, the only ones that are "significant" are the IOV terms associated with V1 and V2, both more than 30%. Now I can understand how CL can vary from occasion to occasion, but I have a hard time understanding how V1 and V2 can vary from occasion to occasion. I would also have a hard time interpreting IOV on Q, but that was not the case here. So my question is, can someone provide me with a reasonable rationale for why volume terms or intercompartmental clearance would change from day to day because right now I am convinced this is modeling nonsense. Thanks, Pete bonate Peter L. Bonate, PhD, FCP Director, Pharmacokinetics Genzyme Corporation 4545 Horizon Hill Blvd San Antonio, TX 78229 phone: 210-949-8662 fax: 210-949-8219 email: peter.bonate@genzyme.com