Re: Interpreting IOV

From: j.bulitta@web.de Subject: Re: [NMusers] Interpreting IOV Date: Fri, 16 Sep 2005 02:27:16 +0200 Dear Dr Bonate, in case you have a rather short (<15 min) duration of infusion and "frequent" samples within 5-20 min after end of the infusion, you may observe IOV in V1 which may be influenced by the distribution of arterial and venous blood. I saw a few datasets when the peak concentration was actually 5-15 min after end of the iv infusion instead of at the end of infusion for about 30% (depending on the drug) of the subjects. I did not have replicated doses for those datasets and could not include IOV. However, dosing the zero order input into a mixing compartment ("gut") and not into the central compartment improved the objective function typically by >50 points for those datasets with frequent blood sampling. Best regards Juergen ------------------------- Juergen Bulitta, M.Sc. Research Scientist IBMP - Institute for Biomedical and Pharmaceutical Research Paul-Ehrlich-Strasse 19 90562 Nurnberg - Heroldsberg Germany