RE: Indirect response PD model
From: "Tsai, Max" max.tsai@spcorp.com
Subject: RE: [NMusers] Indirect response PD model
Date: Tue, February 1, 2005 12:59 pm
I agree that the 4 compartment setup is not necessary if the plasma
concentrations from the PK model are entered into the dataset and the
control stream is coded properly. However, I thought that since there is no
mass actually being transferred to the effect compartment in the indirect
response model, there is no need for a rate constant such as k1e to link the
effect compartment and the central compartment, in my case. If anyone else
in the users group would like to comment on this issue, please feel free.
-Max