Re: Indirect response PD model
From: "mathangi" mathangi@msn.com
Subject: Re: [NMusers] Indirect response PD model
Date: Fri, January 28, 2005 7:11 pm
Hello Max,
The indirect model you have used requires initialization
of baseline response. It could be done the following way
in the data set and control file.
CONTROL FILE
;PD MODEL
TVKIN = THETA(1)
TVKOUT = THETA(2)
TVIC50 = THETA(3)
KIN = TVKIN * EXP(ETA(1))
KOUT = TVKOUT * EXP(ETA(2))
IC50 = TVIC50 * EXP(ETA(3))
F4 = KIN/KOUT ;Initializing to baseline; R0 = kin/kout
DATA SET
101 10 0 . 1
101 1 0 0 4
101 . 0 6.4 4
101 . 2 5.7 4
101 . 4 4.9 4
101 . 6 3.8 4
101 . 8 3.5 4
101 . 12 2.2 4
101 . 24 2.4 4
The modified model runs successfully. Hope this is helpful.
Just a suggestion.
Parametrizing in terms of CL and V would lead to meaningful interpretation of the model.
Thanks
Mathangi