RE: Indirect response PD model

From: "Tendolkar, Amol" amol.tendolkar@spcorp.com Subject: RE: [NMusers] Indirect response PD model Date: Tue, February 1, 2005 5:29 am Hi Max, Before you apply a programmatic solution to this problem, I would like to point out that the Indirect Pharmacologic Response model could be set up as a Direct or Indirect link model. It appears from your model setup, that you have an effect compartment, however, you have not linked it to either peripheral or central compartment with 'keo'. I also noticed that you are not simultaneously fitting pk and pd models. Therefore, you do not need a 4 compartment setup. A 1 compartment model (just for the response variable) should be adequate. Amol