RE: sample size

From: "GIRARD PASCAL" PASCAL.GIRARD@adm.univ-lyon1.fr Subject: RE: [NMusers] sample size Date: Mon, November 15, 2004 4:44 am Hi Mats and All, The initial question of Vijay was: "I am aware that NONMEM can be used for modelling single subject data but will n=4 suffice for population analysis?. My answer still is that I don't think anyone can pretend building a population model with n=4. Now if the question is "May I take advantage of population framework for estimating individual parameters, and get better results than modelling single subject?" I agree that it may be worth trying. You simply have to keep in mind that the objective of this initial analysis with n=4 is getting "individual parameters", not population ones. Now I agree that it can also be considered as the very first step of a population analysis. For this latter objective, Vijay could use Steve's suggestion which is assessing how much mammals, points/mammals as well as value of sample times that would be necessary to estimate, with a certain requested precision, the population parameters. Best regards, Pascal