RE: sample size

From: "Steve Duffull" sduffull@pharmacy.uq.edu.au Subject: RE: [NMusers] sample size Date: Sun, November 14, 2004 5:38 pm Hi Vijay (Pascal + Mats) In addition to the comments already - you could compute the amount of information in your current design and then get a feeling for how well a population method would be able to solve your problem. This would allow you to assess whether the design is sufficient to meet your needs vs the slightly different question does a particular tool (e.g. NONMEM) perform well with the data that you have. To do this, you would need to have some feeling as to what the most likely model and parameter values are, and it may well turn out that in some circumstances it is possible to learn about some parameters from as little as 4 intensively sampled subjects. If you have the sampling design, and some feeling for the likely model(s) and parameter values then I am happy to compute the information from the design for you... Steve Stephen Duffull School of Pharmacy University of Queensland Brisbane 4072 Australia Tel +61 7 3365 8808 Fax +61 7 3365 1688 University Provider Number: 00025B Email: sduffull@pharmacy.uq.edu.au www: http://www.uq.edu.au/pharmacy/sduffull/duffull.htm PFIM: http://www.uq.edu.au/pharmacy/sduffull/pfim.htm MCMC PK example: http://www.uq.edu.au/pharmacy/sduffull/MCMC_eg.htm