Re: Bayesian estimation: a specific case

From: Pierre Maitre <maitre@cdg.ch> Subject: Re: Bayesian estimation: a specific case Date: Wed, 04 Oct 2000 21:29:05 +0200 Quyen.Ho-Nguyen@serono.com wrote: > > The question is: can I use the model of pop1 to calculate the Posthoc PK > (CL, V, etc...) of pop2? Sure, if 1) you believe that pop1 and pop2 are subgroups of the same population 2) the conditions and admistration scheme used in pop2 are not too different from thoses used in pop1 > Is it relevant to apply the PK model found in Pop1 to the Pop2, > even if data of Pop2 can not describe this model, due to a low > number of samples per patient in Pop2 and to the complicated PK model? Yes, that's exactly the purpose of Bayesian regression. Best regards Pierre Maitre