Bayesian estimation

From: Quyen.Ho-Nguyen@serono.com Subject: Bayesian estimation Date: Fri, 29 Sep 2000 11:25:11 +0100 Dear NONMEM users, We would like to obtain Bayesian estimation of PK parameters for each subject. In fact, I have a population 1 on which I performed population PK analysis and using the POSTHOC option I obtained the individual PK parameters for this Pop1. I have a Pop2 (concentration of the drug). Based on the fact that the PK of the drug is similar between Pop1 and Pop2, I would like to obtain the individual PK parameters (CL, V, etc...) for the Pop2, using information obtained in Pop1. Has anybody already used this methodology using NONMEM (or another tool?). thanks in advance for your help Quyen Ho-Nguyen, Pharm D. Serono International S.A