Re: PD initialization
From: "Jogarao Gobburu 301-594-5354 FAX 301-480-3212" <GOBBURUJ@cder.fda.gov>
Subject: Re: PD initialization
Date: Mon, 09 Oct 2000 13:39:52 -0400 (EDT)
Hello,
1. Should F2=THETA() be used, one should make sure that either Kin or Kout is reparameterized with respect to F2. For eg: Kout=THETA(1), F2=THETA(2) => Kin=Kout*F2.
2. I personally prefer to use inter-individual variability on Kin and Kout rather than the baseline value itself. This ensures more mechanistic interpretation of the results.
Regards,
Joga Gobburu
Pharmacometrics
CDER, FDA.