PD initialization

From: Sriram Krishnaswami <ksriram@ufl.edu> Subject: PD initialization Date: Mon, 09 Oct 2000 14:53:39 +1000 Hello, We tried another way to solve this problem. Without putting AMT=1 at t=0 or making any changes/additions to the control stream, or adding SS to the data file, we tried the following with the data file. Just add two records for each subject (for ex. time 0 and time 12 with DVs=0 and MDVs=1) and shift the whole analysis by say 24 hours. i.e the drug dose is given at 24 hours. E0 is the observed DV value at 24 hours. In this case the PD value starts at zero at time 0 and increases with time until it reaches steady state. In other words, we allow sufficient time for the PD to reach steady state before the drug is administered. This method seems to work just fine. Any suggestions on its validity? Thanks Sriram Sriram Krishnaswami Graduate student Dept. of Pharmaceutics College of Pharmacy University of Florida Gainesville, FL 32610-0494 Home: 352 846 5968 Lab: 352 846 3257 Fax: 352 392 4447