Re: PD initialization

From: "Jogarao Gobburu 301-594-5354 FAX 301-480-3212" <GOBBURUJ@cder.fda.gov> Subject: Re: PD initialization Date: Fri, 06 Oct 2000 08:55:59 -0400 (EDT) Hello, 1. Another way to code this is to include SS data item(=1 for CMT=2,else =0 if pk is not at steady-state) to specify that PD is at steady-state before dosing. You have to provide another data record for your 'observation', as you do with most PK problems. AMT=0 indicates steady-state with constant rate infusion (see help guide 'AMT'). eg: #ID TIME AMT SS CMT DV ... 1 0 0 1 2 . 1 0 . 0 2 10 1 0 100 0 1 . 2. You might want to consider re-parameterizing your equation in terms of CL (and V) rather than k, if applicable. Regards, Joga Gobburu Pharmacometrics, CDER, FDA.