RE: PD initialization

From: "nelamangala nagaraja" <nvnagaraj@hotmail.com> Subject: RE: PD initialization Date: Fri, 06 Oct 2000 12:57:45 EDT Hi all, The suggestion by Dr.Piotrovskij is that we add an AMT data at time=0 for initializing the PD parameter. In fact myself and Atul were attempting the same way and it has a bug in it. It does not FIT the PD data at time=0. Instead, if we give a value of (say) 3.5 (which is actually the concentration at t=0) as the AMT, the PRED will be 3.5 (at t=0). In the second subject, if we give 4.5 as AMT, PRED will return as 4.5. Is there any alternative way of fitting E0? Raj Nelamangala V. Nagaraja, PhD Post Doc Res Assoc Department of Pharmaceutics, University of Florida, Gainesville, FL-32610 Ph: 352-846-3257 Fax: 352-392-4447