RE: PD initialization
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com>
Subject: RE: PD initialization
Date: Fri, 6 Oct 2000 13:23:17 +0200
Atul,
The NONMEM users guide is rather vague as usual. What you have to do is initializing CMT 2 by putting a dummy AMT equal to 1 at time 0. Then you should pass the baseline level of A(2) (which is K0/KE) to $DES via F2:
$PK
...
F2 = K0/KE
Hope this helps.
Best regards,
Vladimir
----------------------------------------------------------------------
Vladimir Piotrovsky, Ph.D.
Janssen Research Foundation
Human Pharmacokinetics (ext. 5463)
B-2340 Beerse
Belgium
Email: vpiotrov@janbe.jnj.com