RE: Negative objective functions

From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com> Subject: RE: Negative objective functions Date: Fri, 30 Oct 1998 12:23:36 +0100 The default objective function in NONMEM is that of ELS, and it can be positive or negative depending on DV units, number of measurements, etc. In NONMEM V, it is possible to select an objective function equal to likelihood or -2*log(likelihood) by including LIKELIHOOD or -2LOGLIKELIHOOD option, respectively, in $ESTIMATION. Vladimir ---------------------------------------------------------- Vladimir Piotrovsky Clinical Pharmacokinetics Janssen Research Foundation 2340 Beerse, Belgium e-mail: vpiotrov@janbe.jnj.com