Re: Negative objective functions

From: "Rik Schoemaker" <RS@chdr.nl> Subject: Re: Negative objective functions Date: Fri, 30 Oct 1998 08:45:30 +0100 Dear James, The minimum value of the objective function is equal to twice the logarithm of the likelihood. If the likelihood is smaller than 1, the log will be negative. The likelihood itself is influenced by the scaling of the measurements; changing for instance from concentrations in ng/mL to ng/L will change the value of the likelihood. Regards, Rik Schoemaker CHDR, Leiden, Netherlands