Re: covariate models
From PRADHANR@cder.fda.gov Thu Jun 12 05:14:19 1997
Subject: Re: covariate models
Ralf,
In my experience, I have compared the following situation:
1.TVV1 = THETA(1) * (WT)**THETA(2)
VS.
2.TVV1 = THETA(1) * (WT/70)**THETA(2)
In a covariate rich model, #2 computationally performed better. In other words OFV minimization reached much sooner. Any comments would be appreciated.
Thank you
Raj Pradhan, Ph.D.
OCPB, FDA