Re: covariate models

From: Rene Braeckman Date: June 11, 1997 technical Source: cognigencorp.com
From Rene_Braeckman@cc.chiron.com Wed Jun 11 11:05:34 1997 Subject: Re: covariate models The two methods differ in the interpretation of THETA(1) and THETA(2), as follows: a) THETA(1): part of V independent of WT THETA(2): change of V per unit WT (WT-dependent part) b) THETA(1): part of V for 70-kg WT THETA(2): change of V per unit of WT different from the standard 70-kg WT Method a) implies that there is a value for V equal to THETA(1) at a WT of zero, which is theoretically not possible. Method b) gives a direct estimate for V (THETA(1)) for a standard 70-kg person. Rene Braeckman, PhD Senior Director of Pharmacokinetics & Pharmacodynamics Chiron Corp., Emeryville, CA

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Jun 11, 1997 Ralf Brueckner covariate models
Jun 11, 1997 Rene Braeckman Re: covariate models
Jun 11, 1997 Ferrin Harrison Re: covariate models
Jun 12, 1997 Pradhanr Re: covariate models
Jun 12, 1997 Ferdinand Rombout Antwort: RE: COVARIATE MODELS
Jun 12, 1997 Ralf Brueckner Covariate Models
Jun 12, 1997 Rene Braeckman Re[2]: covariate models
Jun 13, 1997 Vladimir Piotrovskij Gender as a covariate
Jun 13, 1997 Rik Schoemaker Re: Covariate Models
Jun 13, 1997 Rik Schoemaker Re: Re[2]: Covariate Models
Jun 13, 1997 Ferrin Harrison interpretable models
Jun 14, 1997 Ene Ette Re: Gender as a covariate
? Unknown Re[2]: Covariate Models
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