Re: Gender as a covariate

From: Ene Ette Date: June 14, 1997 technical Source: cognigencorp.com
From ETTEE@cder.fda.gov Sat Jun 14 12:43:42 1997 Subject: Re: Gender as a covariate I think that there is an over generalization on the issue of gender as covariate. It is worth noting that there may still be a gender effect on clearance (CL) after adjustment has been made for weight. This has been observed with some drugs. Omitting a gender effect (when present) because adjustment for weight has been made may have serious consequences. With data visualization, is a useful tool for informative population modeling, this error can be avoided. Ene Ette, Ph.D. Pharmacometrics Staff Office of Clinical Pharmacology & Biopharmaceutics FDA

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Jun 11, 1997 Ralf Brueckner covariate models
Jun 11, 1997 Rene Braeckman Re: covariate models
Jun 11, 1997 Ferrin Harrison Re: covariate models
Jun 12, 1997 Pradhanr Re: covariate models
Jun 12, 1997 Ferdinand Rombout Antwort: RE: COVARIATE MODELS
Jun 12, 1997 Ralf Brueckner Covariate Models
Jun 12, 1997 Rene Braeckman Re[2]: covariate models
Jun 13, 1997 Vladimir Piotrovskij Gender as a covariate
Jun 13, 1997 Rik Schoemaker Re: Covariate Models
Jun 13, 1997 Rik Schoemaker Re: Re[2]: Covariate Models
Jun 13, 1997 Ferrin Harrison interpretable models
Jun 14, 1997 Ene Ette Re: Gender as a covariate
? Unknown Re[2]: Covariate Models
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