covariate models

From: Ralf Brueckner Date: June 11, 1997 technical Source: cognigencorp.com
From ltc_Ralf_Brueckner@wrsmtp-ccmail.army.mil Wed Jun 11 09:16:28 1997 Subject: covariate models Dear fellow NONMEM users, I have seen covariate models expressed as: a) V = THETA(1)+THETA(2)*WT and as b) V = THETA(1)+THETA(2)*(WT-70) so called "centering the covariates at their median". Can someone explain the rationale for the second method. Method a seems intuitively more useful as a clinician. Thank you Ralf Brueckner, MD Dept. of Clinical Pharmacology Div. of Experimental Therapeutics Walter Reed Army Institute of Research

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Jun 11, 1997 Ralf Brueckner covariate models
Jun 11, 1997 Rene Braeckman Re: covariate models
Jun 11, 1997 Ferrin Harrison Re: covariate models
Jun 12, 1997 Pradhanr Re: covariate models
Jun 12, 1997 Ferdinand Rombout Antwort: RE: COVARIATE MODELS
Jun 12, 1997 Ralf Brueckner Covariate Models
Jun 12, 1997 Rene Braeckman Re[2]: covariate models
Jun 13, 1997 Vladimir Piotrovskij Gender as a covariate
Jun 13, 1997 Rik Schoemaker Re: Covariate Models
Jun 13, 1997 Rik Schoemaker Re: Re[2]: Covariate Models
Jun 13, 1997 Ferrin Harrison interpretable models
Jun 14, 1997 Ene Ette Re: Gender as a covariate
? Unknown Re[2]: Covariate Models
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