Using Root-finding techniques to find Cmax/Tmax

2 messages 2 people Latest: May 14, 2018

Using Root-finding techniques to find Cmax/Tmax

From: Robert Bauer Date: May 14, 2018 technical
Dear nmusers: Because of the recent discussions (topic "Cmax/Tmax in the DES block") on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view the accompanying example files, located in https://nonmem.iconplc.com/nonmem/cmax_root_finder Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com/

RE: Using Root-finding techniques to find Cmax/Tmax

From: Nick Holford Date: May 14, 2018 technical
Hi Bob, Thanks for preparing the examples. I found the “nonmem reserved general” file something of a challenge – I could barely understand a line of it. Any chance you could zip up all the files into one archive file? I find myself faced with downloading a couple of pages of files one file at a time. Best wishes, Nick -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72 email: [email protected] http://holford.fmhs.auckland.ac.nz/ http://orcid.org/0000-0002-4031-2514 Read the question, answer the question, attempt all questions
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From: [email protected] <[email protected]> On Behalf Of Bauer, Robert Sent: Monday, May 14, 2018 5:55 PM To: [email protected] Subject: [NMusers] Using Root-finding techniques to find Cmax/Tmax Dear nmusers: Because of the recent discussions (topic “Cmax/Tmax in the DES block”) on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view the accompanying example files, located in https://nonmem.iconplc.com/nonmem/cmax_root_finder Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com/