RE: Using Root-finding techniques to find Cmax/Tmax
Hi Bob,
Thanks for preparing the examples. I found the “nonmem reserved general” file
something of a challenge – I could barely understand a line of it.
Any chance you could zip up all the files into one archive file? I find myself
faced with downloading a couple of pages of files one file at a time.
Best wishes,
Nick
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 FR+33(6)62 32 46 72
email: [email protected]
http://holford.fmhs.auckland.ac.nz/
http://orcid.org/0000-0002-4031-2514
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Quoted reply history
From: [email protected] <[email protected]> On Behalf Of
Bauer, Robert
Sent: Monday, May 14, 2018 5:55 PM
To: [email protected]
Subject: [NMusers] Using Root-finding techniques to find Cmax/Tmax
Dear nmusers:
Because of the recent discussions (topic “Cmax/Tmax in the DES block”) on the
proper way of obtaining tmax and cmax with ODE solvers, I have been motivated
to provide some examples utilizing root-finding techniques available in ADVAN14
(CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view
the accompanying example files, located in
https://nonmem.iconplc.com/nonmem/cmax_root_finder
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com/