Using Root-finding techniques to find Cmax/Tmax

Dear nmusers: Because of the recent discussions (topic "Cmax/Tmax in the DES block") on the proper way of obtaining tmax and cmax with ODE solvers, I have been motivated to provide some examples utilizing root-finding techniques available in ADVAN14 (CVODES) and ADVAN15 (IDAS). Please read the cmax_root_finder.pdf, and view the accompanying example files, located in https://nonmem.iconplc.com/nonmem/cmax_root_finder Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com/