Troubleshooting installation of nonmembers 7.5 on Mac with silicon M1 CPU

6 messages 6 people Latest: Apr 28, 2021
Hi all, I am trying to install nonmem 7.5 on my new mac, with an Apple silicon (M1) CPU, but I am unsuccessful thusfar. I have done the following: 1. Installed xcode command line tools 2. Installed gfortran for silicon m1 CPUs from https://github.com/fxcoudert/gfortran-for-macOS/releases/tag/11-arm-alpha2 3. Followed the instructions for the right path, and copied the files from https://nonmem.iconplc.com/nonmem750/MACOSX/ to the right folder inside the nonmem installation folder nm750cd, as instructed by the readme_MACOSX.txt file 4. Started the installation from a terminal window using the command “sudo /bin/bash SETUP75std $HOME/Downloads/nm750CD $HOME/nm750 gfortran y ar same rec i” However, installation fails with the following message: Step 6. Compile resource files SETUP75std: line 523: 15300 Abort trap: 6 ./install 2 $zf $zu $f "$op" "$mod" Linux "$u -a" o $pipe x > $msgs 2>&1 Compile of resource files failed. Please look for error messages in /Users/robterheine/nm750/compilemsgs.txt and /Users/robterheine/nm750/finishmsgs.txt If I open these message files I see the following: dyld: Library not loaded: /usr/local/gfortran/lib/libquadmath.0.dylib Referenced from: /Users/robterheine/nm750/./install Reason: image not found It indeed seems that libqyadmath.0.dylib is not present on my drive. Does anyone have suggestions how to get the installation working? Sincerely, Rob De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. The content of this message is intended solely for the addressee. No rights can be derived from this message or its attachments. If you are not the intended recipient, we kindly request you to delete the message and inform the sender. It is strictly prohibited to disclose, copy or distribute this email or the information inside it, without a written consent from the sender. Radboud university medical center is registered with the Dutch Chamber of Commerce trade register with number 80262783.
Dear Rob. I got this error solved previously by installing also gfortran anew. My impression was that the xcode installation messed gfortran somehow up. Best wishes, Teijo
Quoted reply history
On 28.4.2021 11.55, Heine, Rob ter wrote: > Hi all, > > I am trying to install nonmem 7.5 on my new mac, with an Apple silicon (M1) CPU, but I am unsuccessful thusfar. > > I have done the following: > > 1. Installed xcode command line tools > 2. Installed gfortran for silicon m1 CPUs from > https://github.com/fxcoudert/gfortran-for-macOS/releases/tag/11-arm-alpha2 > > 3. Followed the instructions for the right path, and copied the files > from https://nonmem.iconplc.com/nonmem750/MACOSX/ to the right > folder inside the nonmem installation folder nm750cd, as > instructed by the readme_MACOSX.txt file > 4. Started the installation from a terminal window using the command > “sudo /bin/bash SETUP75std $HOME/Downloads/nm750CD $HOME/nm750 > gfortran y ar same rec i” > > However, installation fails with the following message: > > Step 6. Compile resource files > > SETUP75std: line 523: 15300 Abort trap: 6 ./install 2 $zf $zu $f "$op" "$mod" Linux "$u -a" o $pipe x > $msgs 2>&1 > > Compile of resource files failed. > > Please look for error messages in /Users/robterheine/nm750/compilemsgs.txt and /Users/robterheine/nm750/finishmsgs.txt > > If I open these message files I see the following: > > dyld: Library not loaded: /usr/local/gfortran/lib/libquadmath.0.dylib > > Referenced from: /Users/robterheine/nm750/./install > > Reason: image not found > > It indeed seems that libqyadmath.0.dylib is not present on my drive. > > Does anyone have suggestions how to get the installation working? > > Sincerely, > > Rob > > De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. > > The content of this message is intended solely for the addressee. No rights can be derived from this message or its attachments. If you are not the intended recipient, we kindly request you to delete the message and inform the sender. It is strictly prohibited to disclose, copy or distribute this email or the information inside it, without a written consent from the sender. Radboud university medical center is registered with the Dutch Chamber of Commerce trade register with number 80262783.
Please try this option - Dynamic libraries changed on Big Sur so the linker could not find libSystem. You have to install the right SDKs by running `xcode-select --install` (see also: https://developer.apple.com/forums/thread/655588en https://github.com/ponylang/ponyc/issues/3684). Chandramouli
Quoted reply history
From: [email protected] <[email protected]> On Behalf Of Teijo Saari Sent: Wednesday, April 28, 2021 8:28 PM To: Heine, Rob ter <[email protected]>; [email protected] Subject: Re: [NMusers] Troubleshooting installation of nonmembers 7.5 on Mac with silicon M1 CPU CAUTION: This email originated from outside of Certara. Do not click links or open attachments unless you recognize the sender and know the content is safe. Might work. I did fresh installation after hearing so much about problems with recent OSX and Xcode. Teijo On 28.4.2021 12.54, Heine, Rob ter wrote: Hi Teijo, I did install gfortran again, but it did not help. Should I remove xcode as well? Sincerely, Rob Van: Teijo Saari <[email protected]><mailto:[email protected]> Datum: woensdag 28 april 2021 om 11:19 Aan: "Heine, Rob ter" <[email protected]><mailto:[email protected]>, "[email protected]"<mailto:[email protected]> <[email protected]><mailto:[email protected]> Onderwerp: Re: [NMusers] Troubleshooting installation of nonmembers 7.5 on Mac with silicon M1 CPU Dear Rob. I got this error solved previously by installing also gfortran anew. My impression was that the xcode installation messed gfortran somehow up. Best wishes, Teijo On 28.4.2021 11.55, Heine, Rob ter wrote: Hi all, I am trying to install nonmem 7.5 on my new mac, with an Apple silicon (M1) CPU, but I am unsuccessful thusfar. I have done the following: 1. Installed xcode command line tools 2. Installed gfortran for silicon m1 CPUs from https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Ffxcoudert%2Fgfortran-for-macOS%2Freleases%2Ftag%2F11-arm-alpha2&data=04%7C01%7Cchandramouli.radhakrishnan%40certara.com%7C2c43eac9667746e865dc08d90a313bf1%7C7287abd30220456e98514352bae208c9%7C1%7C0%7C637552028856743482%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=KY5Wl4fkEsaixXKItYcoNuPQ87733z8g3aJxltYggng%3D&reserved=0 3. Followed the instructions for the right path, and copied the files from https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnonmem.iconplc.com%2Fnonmem750%2FMACOSX%2F&data=04%7C01%7Cchandramouli.radhakrishnan%40certara.com%7C2c43eac9667746e865dc08d90a313bf1%7C7287abd30220456e98514352bae208c9%7C1%7C0%7C637552028856753472%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=IT4Q9czUS0xtzBDNVf50uEZTkduQ1i4SGoyPm1%2FaF5s%3D&reserved=0 to the right folder inside the nonmem installation folder nm750cd, as instructed by the readme_MACOSX.txt file 4. Started the installation from a terminal window using the command "sudo /bin/bash SETUP75std $HOME/Downloads/nm750CD $HOME/nm750 gfortran y ar same rec i" However, installation fails with the following message: Step 6. Compile resource files SETUP75std: line 523: 15300 Abort trap: 6 ./install 2 $zf $zu $f "$op" "$mod" Linux "$u -a" o $pipe x > $msgs 2>&1 Compile of resource files failed. Please look for error messages in /Users/robterheine/nm750/compilemsgs.txt and /Users/robterheine/nm750/finishmsgs.txt If I open these message files I see the following: dyld: Library not loaded: /usr/local/gfortran/lib/libquadmath.0.dylib Referenced from: /Users/robterheine/nm750/./install Reason: image not found It indeed seems that libqyadmath.0.dylib is not present on my drive. Does anyone have suggestions how to get the installation working? Sincerely, Rob De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. The content of this message is intended solely for the addressee. No rights can be derived from this message or its attachments. If you are not the intended recipient, we kindly request you to delete the message and inform the sender. It is strictly prohibited to disclose, copy or distribute this email or the information inside it, without a written consent from the sender. Radboud university medical center is registered with the Dutch Chamber of Commerce trade register with number 80262783. De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. The content of this message is intended solely for the addressee. No rights can be derived from this message or its attachments. If you are not the intended recipient, we kindly request you to delete the message and inform the sender. It is strictly prohibited to disclose, copy or distribute this email or the information inside it, without a written consent from the sender. Radboud university medical center is registered with the Dutch Chamber of Commerce trade register with number 80262783.
Hi Rob: The following worked for me ( Anything inside ``` refers to a command line) You have at the beginning to locate the file in the system ``` locate libquadmath.0.dylib ``` Then you can check where it is found, usually its in the "usr/local/Cellar/gcc/10.2.0_4/lib/gcc/10/libquadmath.0.dylib" Thus, you link it where nonmem wants it to be ``` ln usr/local/Cellar/gcc/10.2.0_4/lib/gcc/10/libquadmath.0.dylib /usr/local/gfortran/lib/libquadmath.0.dylib ``` Here, you go back to the original setup cd ../nm75CD Then ``` sh SETUP75std $HOME/Downloads/nm75CD $HOME/nm75 gfortran ``` Hope it works for you! Mutaz *-----------------------------------* *Mutaz M. Jaber, PharmD.* *PhD student, Pharmacometrics* *Experimental and Clinical Pharmacology* *University of Minnesota * *717 Delaware St SE; Room 468* *Minneapolis, MN 55414* *Email: [email protected] <[email protected]>* *~ Stay curious*
Quoted reply history
On Wed, Apr 28, 2021 at 6:14 AM Heine, Rob ter <[email protected]> wrote: > Hi Chandramouli, > > > > Xcode and command line tools were already installed (before nonmem > installation) using the “xcode-select --install” command. Again running > this command results in “xcode-select: error: command line tools are > already installed” and does not place the libraries in the folder nonmem > installation script is referring to. > > > > Sincerely, > > Rob > > *Van: *Chandramouli Radhakrishnan <[email protected]> > *Datum: *woensdag 28 april 2021 om 12:57 > *Aan: *Teijo Saari <[email protected]>, "Heine, Rob ter" < > [email protected]>, "[email protected]" < > [email protected]> > *Onderwerp: *RE: [NMusers] Troubleshooting installation of nonmembers 7.5 > on Mac with silicon M1 CPU > > > > Please try this option - > > > > Dynamic libraries changed on Big Sur so the linker could not find > libSystem. You have to install the right SDKs by running `xcode-select > --install` (see also: https://developer.ap...s/thread/655588 > https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdeveloper.apple.com%2Fforums%2Fthread%2F655588&data=04%7C01%7CR.terHeine%40radboudumc.nl%7C97f050740d5e48891c5308d90a3472ae%7Cb208fe69471e48c48d87025e9b9a157f%7C1%7C0%7C637552042657380932%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=cLP2qOCd%2BgB%2FHe58EJ7jkBzCq%2F6d%2FSFh2qL4nbaHpnQ%3D&reserved=0 > en https://github.com/p...c/issues/3684). > https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fponylang%2Fponyc%2Fissues%2F3684).&data=04%7C01%7CR.terHeine%40radboudumc.nl%7C97f050740d5e48891c5308d90a3472ae%7Cb208fe69471e48c48d87025e9b9a157f%7C1%7C0%7C637552042657390886%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=FCDfrT84%2BtjFy3KAeDu2WtLq9qYYxOAYxc1jRsQF%2Bow%3D&reserved=0 > > > > Chandramouli > > > > *From:* [email protected] <[email protected]> *On > Behalf Of *Teijo Saari > *Sent:* Wednesday, April 28, 2021 8:28 PM > *To:* Heine, Rob ter <[email protected]>; [email protected] > *Subject:* Re: [NMusers] Troubleshooting installation of nonmembers 7.5 > on Mac with silicon M1 CPU > > > > CAUTION: This email originated from outside of Certara. Do not click > links or open attachments unless you recognize the sender and know the > content is safe. > > > > > > Might work. I did fresh installation after hearing so much about problems > with recent OSX and Xcode. > > Teijo > > On 28.4.2021 12.54, Heine, Rob ter wrote: > > Hi Teijo, > > > > I did install gfortran again, but it did not help. Should I remove xcode > as well? > > > > Sincerely, > > Rob > > > > *Van: *Teijo Saari <[email protected]> <[email protected]> > *Datum: *woensdag 28 april 2021 om 11:19 > *Aan: *"Heine, Rob ter" <[email protected]> > <[email protected]>, "[email protected]" > <[email protected]> <[email protected]> <[email protected]> > *Onderwerp: *Re: [NMusers] Troubleshooting installation of nonmembers 7.5 > on Mac with silicon M1 CPU > > > > Dear Rob. > > I got this error solved previously by installing also gfortran anew. My > impression was that the xcode installation messed gfortran somehow up. > > Best wishes, > > Teijo > > On 28.4.2021 11.55, Heine, Rob ter wrote: > > Hi all, > > > > I am trying to install nonmem 7.5 on my new mac, with an Apple silicon > (M1) CPU, but I am unsuccessful thusfar. > > > > I have done the following: > > > > 1. Installed xcode command line tools > 2. Installed gfortran for silicon m1 CPUs from > https://github.com/fxcoudert/gfortran-for-macOS/releases/tag/11-arm-alpha2 > > https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Ffxcoudert%2Fgfortran-for-macOS%2Freleases%2Ftag%2F11-arm-alpha2&data=04%7C01%7CR.terHeine%40radboudumc.nl%7C97f050740d5e48891c5308d90a3472ae%7Cb208fe69471e48c48d87025e9b9a157f%7C1%7C0%7C637552042657390886%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=cRWlNNXbCnQ0jhka3iI4UmIWf8K6hznGULguUN8r37Y%3D&reserved=0 > 3. Followed the instructions for the right path, and copied the files > from https://nonmem.iconplc.com/nonmem750/MACOSX/ > > https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnonmem.iconplc.com%2Fnonmem750%2FMACOSX%2F&data=04%7C01%7CR.terHeine%40radboudumc.nl%7C97f050740d5e48891c5308d90a3472ae%7Cb208fe69471e48c48d87025e9b9a157f%7C1%7C0%7C637552042657390886%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=0ODaN88jjk4%2FOdh6vKF9ZswipI5z0D%2FMjBQ5wfMq8bk%3D&reserved=0 > to the right folder inside the nonmem installation folder nm750cd, as > instructed by the readme_MACOSX.txt file > 4. Started the installation from a terminal window using the command > “sudo /bin/bash SETUP75std $HOME/Downloads/nm750CD $HOME/nm750 gfortran y > ar same rec i” > > > > However, installation fails with the following message: > > Step 6. Compile resource files > > SETUP75std: line 523: 15300 Abort trap: 6 ./install 2 $zf $zu > $f "$op" "$mod" Linux "$u -a" o $pipe x > $msgs 2>&1 > > Compile of resource files failed. > > > > Please look for error messages in /Users/robterheine/nm750/compilemsgs.txt > and /Users/robterheine/nm750/finishmsgs.txt > > > > If I open these message files I see the following: > > dyld: Library not loaded: /usr/local/gfortran/lib/libquadmath.0.dylib > > Referenced from: /Users/robterheine/nm750/./install > > Reason: image not found > > > > It indeed seems that libqyadmath.0.dylib is not present on my drive. > > > > Does anyone have suggestions how to get the installation working? > > > > Sincerely, > > Rob > > > > *De informatie in dit bericht is uitsluitend bestemd voor de > geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden > ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het > te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en > verspreiden van deze e-mail of informatie uit deze e-mail is alleen > toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het > Radboudumc staat geregistreerd bij de Kamer van Koophandel in het > handelsregister onder nummer 80262783. The content of this message is > intended solely for the addressee. No rights can be derived from this > message or its attachments. If you are not the intended recipient, we > kindly request you to delete the message and inform the sender. It is > strictly prohibited to disclose, copy or distribute this email or the > information inside it, without a written consent from the sender. Radboud > university medical center is registered with the Dutch Chamber of Commerce > trade register with number 80262783. * > > > > *De informatie in dit bericht is uitsluitend bestemd voor de > geadresseerde. Aan dit bericht en de bijlagen kunnen geen rechten worden > ontleend. Heeft u deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het > te vernietigen en de afzender te informeren. Openbaar maken, kopiëren en > verspreiden van deze e-mail of informatie uit deze e-mail is alleen > toegestaan met voorafgaande schriftelijke toestemming van de afzender. Het > Radboudumc staat geregistreerd bij de Kamer van Koophandel in het > handelsregister onder nummer 80262783. The content of this message is > intended solely for the addressee. No rights can be derived from this > message or its attachments. If you are not the intended recipient, we > kindly request you to delete the message and inform the sender. It is > strictly prohibited to disclose, copy or distribute this email or the > information inside it, without a written consent from the sender. Radboud > university medical center is registered with the Dutch Chamber of Commerce > trade register with number 80262783. * > > De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. > Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u > deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en > de afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze > e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande > schriftelijke toestemming van de afzender. Het Radboudumc staat > geregistreerd bij de Kamer van Koophandel in het handelsregister onder > nummer 80262783. > > The content of this message is intended solely for the addressee. No > rights can be derived from this message or its attachments. If you are not > the intended recipient, we kindly request you to delete the message and > inform the sender. It is strictly prohibited to disclose, copy or > distribute this email or the information inside it, without a written > consent from the sender. Radboud university medical center is registered > with the Dutch Chamber of Commerce trade register with number 80262783. >
I think this is using home-brew or other installation of gfortran. I have that dylib in the place the Rob mentioned from the gfortran wiki. David
Quoted reply history
> On Apr 28, 2021, at 11:20 AM, Mu'taz Jaber <[email protected]> wrote: > > Hi Rob: > > The following worked for me ( Anything inside ``` refers to a command line) > > You have at the beginning to locate the file in the system > > ``` > locate libquadmath.0.dylib > ``` > > Then you can check where it is found, usually its in the > "usr/local/Cellar/gcc/10.2.0_4/lib/gcc/10/libquadmath.0.dylib" > > Thus, you link it where nonmem wants it to be > ``` > ln usr/local/Cellar/gcc/10.2.0_4/lib/gcc/10/libquadmath.0.dylib > /usr/local/gfortran/lib/libquadmath.0.dylib > ``` > Here, you go back to the original setup > > cd ../nm75CD > > Then > > ``` > sh SETUP75std $HOME/Downloads/nm75CD $HOME/nm75 gfortran > ``` > > Hope it works for you! > Mutaz > ----------------------------------- > Mutaz M. Jaber, PharmD. > PhD student, Pharmacometrics > Experimental and Clinical Pharmacology > University of Minnesota > 717 Delaware St SE; Room 468 > Minneapolis, MN 55414 > Email: [email protected] > > > ~ Stay curious > > > On Wed, Apr 28, 2021 at 6:14 AM Heine, Rob ter <[email protected]> > wrote: > Hi Chandramouli, > > > > Xcode and command line tools were already installed (before nonmem > installation) using the “xcode-select --install” command. Again running this > command results in “xcode-select: error: command line tools are already > installed” and does not place the libraries in the folder nonmem installation > script is referring to. > > > > Sincerely, > > Rob > > Van: Chandramouli Radhakrishnan <[email protected]> > Datum: woensdag 28 april 2021 om 12:57 > Aan: Teijo Saari <[email protected]>, "Heine, Rob ter" > <[email protected]>, "[email protected]" <[email protected]> > Onderwerp: RE: [NMusers] Troubleshooting installation of nonmembers 7.5 on > Mac with silicon M1 CPU > > > > Please try this option - > > > > Dynamic libraries changed on Big Sur so the linker could not find libSystem. > You have to install the right SDKs by running `xcode-select --install` (see > also: https://developer.ap...s/thread/655588en > https://github.com/p...c/issues/3684). > > > > Chandramouli > > > > From: [email protected] <[email protected]> On Behalf > Of Teijo Saari > Sent: Wednesday, April 28, 2021 8:28 PM > To: Heine, Rob ter <[email protected]>; [email protected] > Subject: Re: [NMusers] Troubleshooting installation of nonmembers 7.5 on Mac > with silicon M1 CPU > > > > CAUTION: This email originated from outside of Certara. Do not click links or > open attachments unless you recognize the sender and know the content is safe. > > > > > > Might work. I did fresh installation after hearing so much about problems > with recent OSX and Xcode. > > Teijo > > On 28.4.2021 12.54, Heine, Rob ter wrote: > > Hi Teijo, > > > > I did install gfortran again, but it did not help. Should I remove xcode as > well? > > > > Sincerely, > > Rob > > > > Van: Teijo Saari <[email protected]> > Datum: woensdag 28 april 2021 om 11:19 > Aan: "Heine, Rob ter" <[email protected]>, "[email protected]" > <[email protected]> > Onderwerp: Re: [NMusers] Troubleshooting installation of nonmembers 7.5 on > Mac with silicon M1 CPU > > > > Dear Rob. > > I got this error solved previously by installing also gfortran anew. My > impression was that the xcode installation messed gfortran somehow up. > > Best wishes, > > Teijo > > On 28.4.2021 11.55, Heine, Rob ter wrote: > > Hi all, > > > > I am trying to install nonmem 7.5 on my new mac, with an Apple silicon (M1) > CPU, but I am unsuccessful thusfar. > > > > I have done the following: > > > > • Installed xcode command line tools > • Installed gfortran for silicon m1 CPUs from > https://github.com/fxcoudert/gfortran-for-macOS/releases/tag/11-arm-alpha2 > • Followed the instructions for the right path, and copied the files > from https://nonmem.iconplc.com/nonmem750/MACOSX/ to the right folder inside > the nonmem installation folder nm750cd, as instructed by the > readme_MACOSX.txt file > • Started the installation from a terminal window using the command > “sudo /bin/bash SETUP75std $HOME/Downloads/nm750CD $HOME/nm750 gfortran y ar > same rec i” > > > However, installation fails with the following message: > > Step 6. Compile resource files > > SETUP75std: line 523: 15300 Abort trap: 6 ./install 2 $zf $zu $f > "$op" "$mod" Linux "$u -a" o $pipe x > $msgs 2>&1 > > Compile of resource files failed. > > > > Please look for error messages in /Users/robterheine/nm750/compilemsgs.txt > and /Users/robterheine/nm750/finishmsgs.txt > > > > If I open these message files I see the following: > > dyld: Library not loaded: /usr/local/gfortran/lib/libquadmath.0.dylib > > Referenced from: /Users/robterheine/nm750/./install > > Reason: image not found > > > > It indeed seems that libqyadmath.0.dylib is not present on my drive. > > > > Does anyone have suggestions how to get the installation working? > > > > Sincerely, > > Rob > > De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. > Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u > deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de > afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze > e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande > schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd > bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. > > The content of this message is intended solely for the addressee. No rights > can be derived from this message or its attachments. If you are not the > intended recipient, we kindly request you to delete the message and inform > the sender. It is strictly prohibited to disclose, copy or distribute this > email or the information inside it, without a written consent from the > sender. Radboud university medical center is registered with the Dutch > Chamber of Commerce trade register with number 80262783. > > De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. > Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u > deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de > afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze > e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande > schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd > bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. > > The content of this message is intended solely for the addressee. No rights > can be derived from this message or its attachments. If you are not the > intended recipient, we kindly request you to delete the message and inform > the sender. It is strictly prohibited to disclose, copy or distribute this > email or the information inside it, without a written consent from the > sender. Radboud university medical center is registered with the Dutch > Chamber of Commerce trade register with number 80262783. > > De informatie in dit bericht is uitsluitend bestemd voor de geadresseerde. > Aan dit bericht en de bijlagen kunnen geen rechten worden ontleend. Heeft u > deze e-mail onbedoeld ontvangen? Dan verzoeken wij u het te vernietigen en de > afzender te informeren. Openbaar maken, kopiëren en verspreiden van deze > e-mail of informatie uit deze e-mail is alleen toegestaan met voorafgaande > schriftelijke toestemming van de afzender. Het Radboudumc staat geregistreerd > bij de Kamer van Koophandel in het handelsregister onder nummer 80262783. > > The content of this message is intended solely for the addressee. No rights > can be derived from this message or its attachments. If you are not the > intended recipient, we kindly request you to delete the message and inform > the sender. It is strictly prohibited to disclose, copy or distribute this > email or the information inside it, without a written consent from the > sender. Radboud university medical center is registered with the Dutch > Chamber of Commerce trade register with number 80262783. >
Hello all: Unfortunately the install_Darwin program located at https://eur02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnonmem.iconplc.com%2Fnonmem750%2FMACOSX%2F&data=04%7C01%7CR.terHeine%40radboudumc.nl%7C97f050740d5e48891c5308d90a3472ae%7Cb208fe69471e48c48d87025e9b9a157f%7C1%7C0%7C637552042657390886%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=0ODaN88jjk4%2FOdh6vKF9ZswipI5z0D%2FMjBQ5wfMq8bk%3D&reserved=0 has not been statically linked, although we thought that it was (seems static linking is very difficult to do in the MAC environment). We have uploaded a new install_Darwin that should not have a dependency on the libquadmath library. Please download it into your nm750CD installer directory, and then make a completely new install (remove the installed directory from a previous attempt). Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com