Log Transformed AST

On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran < [email protected]> wrote: > Dear all, > > I am a PhD student working on NONMEM as a new user. I am working on > external evaluation of some of the selected published population PK models. > While trying to implement one of the models in NONMEM, I realised that if > I code log-transformed aspartate aminotransferase (LAST) as LAST = > LOG(AST), the sdtab output is giving me the In(AST) value instead of a > LOG(AST) value. Was wondering if NONMEM interprets all Log (x) as Log e (x) > instead of Log 10 (x)? > > Thank you. > > Best Regards, > > *Ranita Kirubakaran* > > *PhD Candidate* > > > *Ranita Kirubakaran* > > > > *PhD Candidate* > St Vincent’s Clinical School | *UNSW Sydney* > Department of Clinical Pharmacology and Toxicology > Therapeutics Centre | Level 2 Xavier Building > *St Vincent’s Hospital* > 390 Victoria Street | Darlinghurst NSW 2010 | Australia > > *E* [email protected] | *P* +61 (2) 8382 2199 | *F* +61 > (2) 8382 2724 > >

> On Jul 22, 2019, at 19:49, Duy Tran <[email protected]> wrote: > > If you desire to log transform by base 10 instead of e, use LOG10 in NONMEM > instead of LOG > >> On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran >> <[email protected]> wrote: >> Dear all, >> >> I am a PhD student working on NONMEM as a new user. I am working on external >> evaluation of some of the selected published population PK models. While >> trying to implement one of the models in NONMEM, I realised that if I code >> log-transformed aspartate aminotransferase (LAST) as LAST = LOG(AST), the >> sdtab output is giving me the In(AST) value instead of a LOG(AST) value. >> Was wondering if NONMEM interprets all Log (x) as Log e (x) instead of Log >> 10 (x)? >> >> Thank you. >> >> Best Regards, >> Ranita Kirubakaran >> PhD Candidate >> >> >> Ranita Kirubakaran >> >> PhD Candidate >> St Vincent’s Clinical School | UNSW Sydney >> Department of Clinical Pharmacology and Toxicology >> Therapeutics Centre | Level 2 Xavier Building >> St Vincent’s Hospital >> 390 Victoria Street | Darlinghurst NSW 2010 | Australia >> E [email protected] | P +61 (2) 8382 2199 | F +61 (2) 8382 >> 2724 >> > >

________________________________ From: William Denney <[email protected]> Sent: Tuesday, July 23, 2019 10:04 AM To: Duy Tran <[email protected]> Cc: Ranita Kirubakaran <[email protected]>; [email protected] <[email protected]> Subject: Re: [NMusers] Log Transformed AST Hi Ranita, Duy is correct. NONMEM is based on FORTRAN, so usually the mathematical functions and operators are borrowed from FORTRAN: https://gcc.gnu.org/onlinedocs/gfortran/LOG.html Thanks, Bill On Jul 22, 2019, at 19:49, Duy Tran <[email protected]<mailto:[email protected]>> wrote: If you desire to log transform by base 10 instead of e, use LOG10 in NONMEM instead of LOG On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran <[email protected]<mailto:[email protected]>> wrote: Dear all, I am a PhD student working on NONMEM as a new user. I am working on external evaluation of some of the selected published population PK models. While trying to implement one of the models in NONMEM, I realised that if I code log-transformed aspartate aminotransferase (LAST) as LAST = LOG(AST), the sdtab output is giving me the In(AST) value instead of a LOG(AST) value. Was wondering if NONMEM interprets all Log (x) as Log e (x) instead of Log 10 (x)? Thank you. Best Regards, Ranita Kirubakaran PhD Candidate Ranita Kirubakaran PhD Candidate St Vincent’s Clinical School | UNSW Sydney Department of Clinical Pharmacology and Toxicology Therapeutics Centre | Level 2 Xavier Building St Vincent’s Hospital 390 Victoria Street | Darlinghurst NSW 2010 | Australia E [email protected]<mailto:[email protected]> | P +61 (2) 8382 2199 | F +61 (2) 8382 2724