Re: Log Transformed AST
Hi Ranita,
Duy is correct. NONMEM is based on FORTRAN, so usually the mathematical
functions and operators are borrowed from FORTRAN:
https://gcc.gnu.org/onlinedocs/gfortran/LOG.html
Thanks,
Bill
Quoted reply history
> On Jul 22, 2019, at 19:49, Duy Tran <[email protected]> wrote:
>
> If you desire to log transform by base 10 instead of e, use LOG10 in NONMEM
> instead of LOG
>
>> On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran
>> <[email protected]> wrote:
>> Dear all,
>>
>> I am a PhD student working on NONMEM as a new user. I am working on external
>> evaluation of some of the selected published population PK models. While
>> trying to implement one of the models in NONMEM, I realised that if I code
>> log-transformed aspartate aminotransferase (LAST) as LAST = LOG(AST), the
>> sdtab output is giving me the In(AST) value instead of a LOG(AST) value.
>> Was wondering if NONMEM interprets all Log (x) as Log e (x) instead of Log
>> 10 (x)?
>>
>> Thank you.
>>
>> Best Regards,
>> Ranita Kirubakaran
>> PhD Candidate
>>
>>
>> Ranita Kirubakaran
>>
>> PhD Candidate
>> St Vincent’s Clinical School | UNSW Sydney
>> Department of Clinical Pharmacology and Toxicology
>> Therapeutics Centre | Level 2 Xavier Building
>> St Vincent’s Hospital
>> 390 Victoria Street | Darlinghurst NSW 2010 | Australia
>> E [email protected] | P +61 (2) 8382 2199 | F +61 (2) 8382
>> 2724
>>
>
>