Re: Log Transformed AST

________________________________ From: William Denney <[email protected]> Sent: Tuesday, July 23, 2019 10:04 AM To: Duy Tran <[email protected]> Cc: Ranita Kirubakaran <[email protected]>; [email protected] <[email protected]> Subject: Re: [NMusers] Log Transformed AST Hi Ranita, Duy is correct. NONMEM is based on FORTRAN, so usually the mathematical functions and operators are borrowed from FORTRAN: https://gcc.gnu.org/onlinedocs/gfortran/LOG.html Thanks, Bill On Jul 22, 2019, at 19:49, Duy Tran <[email protected]<mailto:[email protected]>> wrote: If you desire to log transform by base 10 instead of e, use LOG10 in NONMEM instead of LOG On Mon, Jul 22, 2019 at 4:43 PM Ranita Kirubakaran <[email protected]<mailto:[email protected]>> wrote: Dear all, I am a PhD student working on NONMEM as a new user. I am working on external evaluation of some of the selected published population PK models. While trying to implement one of the models in NONMEM, I realised that if I code log-transformed aspartate aminotransferase (LAST) as LAST = LOG(AST), the sdtab output is giving me the In(AST) value instead of a LOG(AST) value. Was wondering if NONMEM interprets all Log (x) as Log e (x) instead of Log 10 (x)? Thank you. Best Regards, Ranita Kirubakaran PhD Candidate Ranita Kirubakaran PhD Candidate St Vincent’s Clinical School | UNSW Sydney Department of Clinical Pharmacology and Toxicology Therapeutics Centre | Level 2 Xavier Building St Vincent’s Hospital 390 Victoria Street | Darlinghurst NSW 2010 | Australia E [email protected]<mailto:[email protected]> | P +61 (2) 8382 2199 | F +61 (2) 8382 2724