Dear colleagues:
I have a very large model (lots of ODEs, lots of data, long duration), running
parallel across several machines, using SAEM. Runs reasonably well. But,
fails the $TABLE with this error:
0PROGRAM TERMINATED BY FNLETA
0PRED EXIT CODE = 1
0INDIVIDUAL NO. 3 ID= 5.10000000000000E+01 (WITHIN-INDIVIDUAL) DATA
REC NO. 1
THETA=
0.00E+00 1.19E+00 2.59E-01 5.68E+00 2.64E-01 5.69E+00 2.35E+00
4.17E-01 4.20E-04 6.50E-01
3.98E-01 1.86E-01 -3.50E-01 -2.09E-01 -1.87E+00 2.09E-01 1.85E-01
-1.90E-01 1.30E+00 4.82E-01
0.00E+00 9.54E-01 1.34E+03 1.19E+00 3.44E-01 1.78E+03
OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0
F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN).
0PROGRAM TERMINATED BY FNLETA
MESSAGE ISSUED FROM TABLE STEP
All the THETA values of 0.00 are fixed to that value. All the other values are
very reasonable.
So, I don't get any tables, can't to a VPC etc. I've tried running FOCE, no
better. Tried error checking that F is always positive, tried EXIT if F is
very small, I have the NOABORT option set (but I don't think that is relevant
in the $TABLE step).
I assume it is crashing calculating the conditional ETAs (don't know why it
does OK in estimation). PRDERR only has the small number of error from the
estimation
Anyone seen this error, any suggestions on how to get rid of it (other than
removeing subject 51)?
Mark
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra, Inc. ™
2525 Meridian Parkway, Suite 280
Research Triangle Park, NC 27713
Office (919)-973-0383
[email protected]<[email protected]>
http://www.nuventra.com
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________________________________
From: [email protected] <[email protected]> on behalf of
nonmem <[email protected]>
Sent: Wednesday, September 23, 2015 6:47 PM
To: Spilker, Mary; [email protected]
Subject: RE: [NMusers] PK-PD Modeling position available (Pfizer Location: La
Jolla, CA)
Dear Mary, l may be over qualified for the position. My current position is
equal to associate director level at Regeneron and my experience exceeds 2
years significantly. Thank you, Pavel
Sent via the Samsung Galaxy S® 5 ACTIVE™, an AT&T 4G LTE smartphone
-------- Original message --------
From: "Spilker, Mary" <[email protected]>
Date: 09/23/2015 12:49 PM (GMT-05:00)
To: [email protected]
Subject: [NMusers] PK-PD Modeling position available (Pfizer Location: La
Jolla, CA)
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