Error in NONMEM 7.2 run

________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Rebecca.L.Neal Sent: Tuesday, July 31, 2012 2:31 PM To: [email protected] Subject: [NMusers] Error in NONMEM 7.2 run All, I am developing a PKPD model and am getting the below error message. Any suggestions or guidance would be appreciated. Thanks! Rebecca Burns Mercer University Post-Doc 0PRED EXIT CODE = 1: Problem=1 Subproblem=0 Superproblem1=0 Iteration1=0 Superproblem2=0 Iteration2=0 0INDIVIDUAL NO. 1 ID= 1.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA REC NO. 1 THETA= 2.56E+00 7.53E+00 4.70E+01 -4.70E+01 2.34E+00 4.06E+01 1.00E+02 1.03E+03 5.98E+01 9.29E+03 2.57E+01 -8.08E+01 4.54E+01 6.33E+03 5.02E+01 9.06E+03 1.14E+02 7.60E+04 4.22E+01 1.19E+04 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0 0END OF PRED EXIT CODE MESSAGES FROM THE ESTIMATION STEP 0END OF MESSAGES: Problem=2 Subproblem=0 Superproblem1=0 Iteration1=0 Superproblem2=0 Iteration2=0 [status]

________________________________ From: Kyun-Seop Bae [[email protected]] Sent: Thursday, August 02, 2012 8:27 PM To: Rebecca.L.Neal Cc: [email protected] Subject: RE: [NMusers] RE: Error in NONMEM 7.2 run Dear Rebecca, We frequently meet that error message. If we literally rephrase, that is EBE (for individual’s PK parameter) could not be found for the subject ID=1. Some of the cases are due to the data preparation error. In this case, after careful examination of the data set for Subject ID=1 (as your error message indicated), you might find some error (for example, omitting dosing event) Some of the cases are intractable. In that case, try omitting that subjects (ID=1) If even after omitting that subject, the model does not run well. Then your model (control) file might be inadequate. Without any error by you, NONMEM or the data could cause that. This may help you. Sincerely, Kyun-Seop ======================= Kyun-Seop Bae MD PhD Associate Professor Department of Clinical Pharmacology and Therapeutics Asan Medical Center, University of Ulsan 88, Olympic-ro 43-gil, Sonpa-gu, Seoul 138-736, Republic of Korea Mobile: +82-10-2791-4611 Tel: +82-2-3010-4611 Fax: +82-2-3010-4623 Email: [email protected] Department Homepage: http://cpt.amc.seoul.kr From: [email protected] [mailto:[email protected]] On Behalf Of Bauer, Robert Sent: Friday, August 03, 2012 6:04 AM To: Rebecca.L.Neal; [email protected] Subject: [NMusers] RE: Error in NONMEM 7.2 run Rebecca: As there is no precise information about the error, it is possible that NONMEM flagged it because a predictive value of F returned an Infinity or Not a number. This could have been cause by a divide by 0 somewhere, or log of a negative number, etc. You should check your code. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Tel: (215) 616-6428 Mob: (925) 286-0769 Email: [email protected]<mailto:[email protected]> Web: http://www.iconplc.com/ ________________________________ From: [email protected]<mailto:[email protected]> [mailto:[email protected]]<mailto:[mailto:[email protected]]> On Behalf Of Rebecca.L.Neal Sent: Tuesday, July 31, 2012 2:31 PM To: [email protected]<mailto:[email protected]> Subject: [NMusers] Error in NONMEM 7.2 run All, I am developing a PKPD model and am getting the below error message. Any suggestions or guidance would be appreciated. Thanks! Rebecca Burns Mercer University Post-Doc 0PRED EXIT CODE = 1: Problem=1 Subproblem=0 Superproblem1=0 Iteration1=0 Superproblem2=0 Iteration2=0 0INDIVIDUAL NO. 1 ID= 1.00000000000000E+00 (WITHIN-INDIVIDUAL) DATA REC NO. 1 THETA= 2.56E+00 7.53E+00 4.70E+01 -4.70E+01 2.34E+00 4.06E+01 1.00E+02 1.03E+03 5.98E+01 9.29E+03 2.57E+01 -8.08E+01 4.54E+01 6.33E+03 5.02E+01 9.06E+03 1.14E+02 7.60E+04 4.22E+01 1.19E+04 OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0 0END OF PRED EXIT CODE MESSAGES FROM THE ESTIMATION STEP 0END OF MESSAGES: Problem=2 Subproblem=0 Superproblem1=0 Iteration1=0 Superproblem2=0 Iteration2=0 [status]