automating the writing of models

4 messages 3 people Latest: Apr 01, 2008

automating the writing of models

From: William Bachman Date: March 31, 2008 technical
Carlos, The closest thing, that I am aware of, to automated models is the Control File Wizards found in PDx-Pop. PDx-Pop provides a graphical user interface to NONMEM that includes creating and running control files (singly or in batch mode), automated diagnostic plots for the runs, and automated model evaluation methods. The Control File Wizards create control files graphically by selecting options you want to include in your model, number of compartments, method of drug administration, parameterization (CL/V vs micro-, macro-constant), etc. You enter parameter values in tables on the screen and can specify estimation methods and table options. I will send you screen shots off-line to give you a better idea. (nmusers has a limit on the size of an email you can send). There are two wizards: one for the standard models (advans 1-4, 10-12) and another for user-written models (advans 5-9). for more information see: http://www.icondevsolutions.com/pdxpop.htm William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 6031 University Blvd., Suite 300 Ellicott City, MD 21043 Office 410-696-3002 Cell 301-467-8635
Quoted reply history
-----Original Message----- From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Dr. Carlos Hoyo Sent: Wednesday, March 19, 2008 10:10 PM To: [email protected] Subject: [NMusers] archive of this list Dear all, How can one access an archive of all the emails of this list? I am looking for tools for automating the writing of models? Is it included in wings? (where). Thanks, Carlos Hoyo [EMAIL PROTECTED] _____________________________________________________________________________________________________________

RE: automating the writing of models

From: Mark Sale Date: March 31, 2008 technical
Carlos I'm not sure what you want to do. DruDevo (www.drudevo.com, don't know if they are still around) has a web site that seems to imply they do some of this: Ø Automated structural model search Automated statistical model search Automated multi level covariate search Ø Automated multi level backwards deletion . Automated multi level covariate search But, I really don't know anything about it. I think that Ken Kawalski's Wald test covariate search approach does some automated control file writing as well, limited (I think) to covariate relationships. Of course, I have to mention my own, which isn't generally available (www.nextlevelsolns.com) but does automate writing control files and searching for the optimal solution. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 > -------- Original Message -------- Subject: [NMusers] automating the writing of models From: "Bachman, William (MYD)" <[EMAIL PROTECTED]> Date: Mon, March 31, 2008 11:04 am To: "Dr. Carlos Hoyo" <[EMAIL PROTECTED]>, > > [email protected] > > Carlos, The closest thing, that I am aware of, to automated models is the Control File Wizards found in PDx-Pop. PDx-Pop provides a graphical user interface to NONMEM that includes creating and running control files (singly or in batch mode), automated diagnostic plots for the runs, and automated model evaluation methods. The Control File Wizards create control files graphically by selecting options you want to include in your model, number of compartments, method of drug administration, parameterization (CL/V vs micro-, macro-constant), etc. You enter parameter values in tables on the screen and can specify estimation methods and table options. I will send you screen shots off-line to give you a better idea. (nmusers has a limit on the size of an email you can send). There are two wizards: one for the standard models (advans 1-4, 10-12) and another for user-written models (advans 5-9). for more information see: > > http://www.icondevsolutions.com/pdxpop.htm > > William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 6031 University Blvd., Suite 300 Ellicott City, MD 21043 Office 410-696-3002 Cell 301-467-8635 -----Original Message----- From: > > owner-nmusers @globomaxnm.com > > [mailto: > > owner-nmusers @globomaxnm.com > > ] On Behalf Of Dr. Carlos Hoyo Sent: Wednesday, March 19, 2008 10:10 PM To: > > nmusers @globomaxnm.com > > Subject: [NMusers] archive of this list Dear all, How can one access an archive of all the emails of this list? I am looking for tools for automating the writing of models? Is it included in wings? (where). Thanks, Carlos Hoyo > > capitanmacintosh @gmail.com > > _____________________________________________________________________________________________________________

Re: automating the writing of models

From: Carlos Hoyo Date: April 01, 2008 technical
I want to run a sequence of models. Let me see your references. Gracias, -- Sent from my iPhone Dr. Carlos Hoyo 5747-3800 new Ext 5438 55-3852-2888 "2008 año de la educación física y el deporte"
Quoted reply history
On Mar 31, 2008, at 10:24 AM, Mark Sale - Next Level Solutions <[EMAIL PROTECTED] > wrote: > <left.letterhead> > Carlos > > I'm not sure what you want to do. DruDevo (www.drudevo.com, don't know if they are still around) has a web site that seems to imply they do some of this: > > Ø Automated structural model search > Automated statistical model search > Automated multi level covariate search > Ø Automated multi level backwards deletion. > Automated multi level covariate search > > But, I really don't know anything about it. > > I think that Ken Kawalski's Wald test covariate search approach does some automated control file writing as well, limited (I think) to covariate relationships. > > Of course, I have to mention my own, which isn't generally available (www.nextlevelsolns.com) but does automate writing control files and searching for the optimal solution. > > Mark Sale MD > Next Level Solutions, LLC > www.NextLevelSolns.com > 919-846-9185 > > -------- Original Message -------- > Subject: [NMusers] automating the writing of models > From: "Bachman, William (MYD)" <[EMAIL PROTECTED]> > Date: Mon, March 31, 2008 11:04 am > To: "Dr. Carlos Hoyo" <[EMAIL PROTECTED]>, > [email protected] > > Carlos, > > The closest thing, that I am aware of, to automated models is the > Control File Wizards found in PDx-Pop. PDx-Pop provides a graphical > user interface to NONMEM that includes creating and running control > files (singly or in batch mode), automated diagnostic plots for the > runs, and automated model evaluation methods. > > The Control File Wizards create control files graphically by selecting > options you want to include in your model, number of compartments, > method of drug administration, parameterization (CL/V vs micro-, > macro-constant), etc. You enter parameter values in tables on the > screen and can specify estimation methods and table options. I will > send you screen shots off-line to give you a better idea. (nmusers has > a limit on the size of an email you can send). > > There are two wizards: one for the standard models (advans 1-4, 10-12) > and another for user-written models (advans 5-9). > > for more information see: http://www.icondevsolutions.com/pdxpop.htm > > William J. Bachman, Ph.D. > Director, Pharmacometrics R&D > Icon Development Solutions > 6031 University Blvd., Suite 300 > Ellicott City, MD 21043 > Office 410-696-3002 > Cell 301-467-8635 > > -----Original Message----- > > From: [EMAIL PROTECTED] [ mailto:[EMAIL PROTECTED] ] > > On Behalf Of Dr. Carlos Hoyo > Sent: Wednesday, March 19, 2008 10:10 PM > To: [email protected] > Subject: [NMusers] archive of this list > > Dear all, > > How can one access an archive of all the emails of this list? > > I am looking for tools for automating the writing of models? Is it > included in wings? (where). > > Thanks, > > Carlos Hoyo > [EMAIL PROTECTED] > > _____________________________________________________________________________________________________________ >

RE: automating the writing of models

From: Mark Sale Date: April 01, 2008 technical
Carlos, I don't have any references for drudevo other than their website, Here is a reference for my work http://www.springerlink.com/content/m7757p17u5058887/ and here is one for Ken Kowalski's paper http://www.springerlink.com/content/r20052w42710217k/ Kens program, last I checked, ran from SAS. and ! here is another for automated covariate search from Nichlas Jonsson and Mats Karlsson http://www.ingentaconnect.com/content/klu/pham/1998/00000015/00000009/00304002;jsessionid=bfi62mem3haid.alexandra There also is an older program from Roberto Gomeni called Visual NM, or Visual NONMEM, not sure it is supported or even available anymore. A very innovative program at the time, probably the first to address running NONMEM in a sort of batch mode with some automation, but I don't think it did any model writing. I think all of these are more special purpose than what you're looking for, but I really don't know what that is. As Bill pointed out, PDx-Pop from Icon/globomax may be your best bet. Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185 Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com 919-846-9185