Hi all,
I wonder if there is an acceptable smallest TOL value for ADVAN6 and what is
it? I searched user guide but did not find the answer. Could anyone share some
information? Thank you.
Xiaofeng
A question about TOL
A suggested value in the NONMEM users guide (NM7.2) for TOL is 9 if you use NSIG=3 and SIGL=9
I would not want to use TOL<3 under any circumstance.
Quoted reply history
On 26/07/2012 6:11 a.m., Wang, Xiaofeng wrote:
> Hi all,
>
> I wonder if there is an acceptable smallest TOL value for ADVAN6 and what is it? I searched user guide but did not find the answer. Could anyone share some information? Thank you.
>
> Xiaofeng
--
Nick Holford, Professor Clinical Pharmacology
First World Conference on Pharmacometrics, 5-7 September 2012
Seoul, Korea http://www.go-wcop.org
Dept Pharmacology & Clinical Pharmacology, Bldg 505 Room 202D
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: [email protected]
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
Xiaofeng,
It depends on how you set NSIG (indicate the number of significant digits that population parameters are to be evaluated at the maximum likelihood).
Further details are provided in Section I.14 Controlling the Precision of the Gradient Evaluation in the introduction to NONMEM 7.1.2 guide.
Below is the general rule that ICON provides:
While some trial and error may still be required by the user for a given problem, certain general rules may be considered.
Set SIGL, NSIG, and TOL such that:
SIGL<=TOL
NSIG<=SIGL/3
This section of the guide also provides information about NONMEM 6.
Luann Phillips
Cognigen Corporation
Director, PK/PD
Wang, Xiaofeng wrote:
> Hi all,
>
> I wonder if there is an acceptable smallest TOL value for ADVAN6 and what is it? I searched user guide but did not find the answer. Could anyone share some information? Thank you.
>
> Xiaofeng
Hi,
I think that the introduction guide to NM7 mentions the following rules for setting the options of numerical integration andestimation:
SIGL <= TOL
NSIG <= SIGL/3
Therefore, SIGL and TOL are conditioned on NSIG.
Sebastien
Wang, Xiaofeng wrote:
> Hi all,
>
> I wonder if there is an acceptable smallest TOL value for ADVAN6 and what is it? I searched user guide but did not find the answer. Could anyone share some information? Thank you.
>
> Xiaofeng
Hi Luann:
My name (both first and last) is very common for Chinese people. Those
questions posted on NONMEN are not from me. If it were me, it would be from
Otsuka email only. But thanks for trying to help me:).
Xiaofeng
PS. Since i have received several emails from old colleagues and friends, i
will start to sign my name as Xiaofeng Wang-Rears , when i post any email on
the NONMEM group.
Quoted reply history
-----Original Message-----
From: Luann Phillips
[[email protected]<mailto:[email protected]>]
Sent: Wednesday, July 25, 2012 06:13 PM Eastern Standard Time
To: Wang, Xiaofeng
Cc: [email protected]
Subject: Re: [NMusers] A question about TOL
Xiaofeng,
It depends on how you set NSIG (indicate the number of significant digits that
population parameters
are to be evaluated at the maximum likelihood).
Further details are provided in Section I.14 Controlling the Precision of the
Gradient Evaluation in
the introduction to NONMEM 7.1.2 guide.
Below is the general rule that ICON provides:
While some trial and error may still be required by the user for a given
problem, certain general
rules may be considered.
Set SIGL, NSIG, and TOL such that:
SIGL<=TOL
NSIG<=SIGL/3
This section of the guide also provides information about NONMEM 6.
Luann Phillips
Cognigen Corporation
Director, PK/PD
Wang, Xiaofeng wrote:
> Hi all,
>
>
>
> I wonder if there is an acceptable smallest TOL value for ADVAN6 and
> what is it? I searched user guide but did not find the answer. Could
> anyone share some information? Thank you.
>
>
>
> Xiaofeng
>
>
>