RE: A question about TOL
Hi Luann:
My name (both first and last) is very common for Chinese people. Those
questions posted on NONMEN are not from me. If it were me, it would be from
Otsuka email only. But thanks for trying to help me:).
Xiaofeng
PS. Since i have received several emails from old colleagues and friends, i
will start to sign my name as Xiaofeng Wang-Rears , when i post any email on
the NONMEM group.
Quoted reply history
-----Original Message-----
From: Luann Phillips
[[email protected]<mailto:[email protected]>]
Sent: Wednesday, July 25, 2012 06:13 PM Eastern Standard Time
To: Wang, Xiaofeng
Cc: [email protected]
Subject: Re: [NMusers] A question about TOL
Xiaofeng,
It depends on how you set NSIG (indicate the number of significant digits that
population parameters
are to be evaluated at the maximum likelihood).
Further details are provided in Section I.14 Controlling the Precision of the
Gradient Evaluation in
the introduction to NONMEM 7.1.2 guide.
Below is the general rule that ICON provides:
While some trial and error may still be required by the user for a given
problem, certain general
rules may be considered.
Set SIGL, NSIG, and TOL such that:
SIGL<=TOL
NSIG<=SIGL/3
This section of the guide also provides information about NONMEM 6.
Luann Phillips
Cognigen Corporation
Director, PK/PD
Wang, Xiaofeng wrote:
> Hi all,
>
>
>
> I wonder if there is an acceptable smallest TOL value for ADVAN6 and
> what is it? I searched user guide but did not find the answer. Could
> anyone share some information? Thank you.
>
>
>
> Xiaofeng
>
>
>