Re: A question about TOL

Xiaofeng, It depends on how you set NSIG (indicate the number of significant digits that population parameters are to be evaluated at the maximum likelihood). Further details are provided in Section I.14 Controlling the Precision of the Gradient Evaluation in the introduction to NONMEM 7.1.2 guide. Below is the general rule that ICON provides: While some trial and error may still be required by the user for a given problem, certain general rules may be considered. Set SIGL, NSIG, and TOL such that: SIGL<=TOL NSIG<=SIGL/3 This section of the guide also provides information about NONMEM 6. Luann Phillips Cognigen Corporation Director, PK/PD Wang, Xiaofeng wrote: > Hi all, > > I wonder if there is an acceptable smallest TOL value for ADVAN6 and what is it? I searched user guide but did not find the answer. Could anyone share some information? Thank you. > > Xiaofeng