Extreme values of CWRESI in NONMEM 7.4.1?

Paolo: I reviewed my NONMEM 7.4 testing results on CWRESI, and they provide the same values in NONMEM 7.3 as well as NONMEM 7.4. In case you ran the problem in parallel, because NONMEM 7.4 now executes the diagnostic evaluation in parallel as well, I tested under parallel execution conditions, and the CWRESI values are also the same between NONMEM 7.4 (parallel) and NONMEM 7.3. Incidentally, as a diagnostic that is expected to be normally distributed when the model is correct, CWRES is preferred even when INTERACTION is used in the $EST step. I would be happy to run your problem and see if I can detect something more subtle that is involved in your case. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com/