AW: Extreme values of CWRESI in NONMEM 7.4.1?

Hi Paolo and Rob, I’ve been experiencing similarly large CWRES (no “I”) values with NM7.4.1 for models which produced reasonable values when run unchanged in NM7.3. Other colleagues also saw this behavior. I believe we typically see it with bigger/more complex models (can’t recall a case where we had the problem with an analytical ADVAN). Since computation of CWRES is parallelized since 7.4.1, so I guess something about the implementation may have been changed to enable this. I haven’t tried it myself, but if the “old” code is still used when the computation is not parallelized, one could speculate that disabling parallel evaluation of the residuals might help. The one thing I tried that did not help was using WRESCHOL. Kind Regards, Sven Von: [email protected] [mailto:[email protected]] Im Auftrag von Bauer, Robert Gesendet: Donnerstag, 16. November 2017 19:46 An: [email protected] Betreff: [NMusers] Extreme values of CWRESI in NONMEM 7.4.1? Paolo: I reviewed my NONMEM 7.4 testing results on CWRESI, and they provide the same values in NONMEM 7.3 as well as NONMEM 7.4. In case you ran the problem in parallel, because NONMEM 7.4 now executes the diagnostic evaluation in parallel as well, I tested under parallel execution conditions, and the CWRESI values are also the same between NONMEM 7.4 (parallel) and NONMEM 7.3. Incidentally, as a diagnostic that is expected to be normally distributed when the model is correct, CWRES is preferred even when INTERACTION is used in the $EST step. I would be happy to run your problem and see if I can detect something more subtle that is involved in your case. Robert J. Bauer, Ph.D. Senior Director Pharmacometrics R&D ICON Early Phase 820 W. Diamond Avenue Suite 100 Gaithersburg, MD 20878 Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> http://www.iconplc.com/