Re: Correcting for salt vs. base

I prefer converting dose to the base. The advantages I see is that the resulting PK parameter values can be more correctly interpreted in the context of physiologic processes (hepatic blood flow, GFR, absolute bioavailability etc). Edmund At 05:57 AM 3/26/2014, Fisher Dennis wrote: > Colleagues > > I have been troubled by a minor issue for some time. Consider the following situation: > > Dose is reported in mg salt > Cp is reported in ng/ml base > > Since CL is dose / AUC and AUC is merely the integral of Cp vs. time, in theory, dose should be converted to mg base (or concentration to ng/ml salt). > > However, I am not sure if everyone does that. > > In fact, an argument against it is that not doing the conversion permits one to relate the administered dose (which is usually based on salt) to a Cp value (usually based on base). > > I am interested to hear what approach people use. > > Dennis > > Dennis Fisher MD > P < (The "P Less Than" Company) > Phone: 1-866-PLessThan (1-866-753-7784) > Fax: 1-866-PLessThan (1-866-753-7784) > http://www.plessthan.com/www.PLessThan.com Edmund V. Capparelli, Pharm.D. Professor of Clinical Pediatrics and Clinical Pharmacy Director, Center for Research in Pediatric and Developmental Pharmacology (RPDP) Pediatric Pharmacology and Drug Discovery University of California, San Diego 858-246-0009 (telephone) 858-534-5611 (fax)