RE: Correcting for salt vs. base
Hi Dennis,
We typically convert the dose to mg-eq of the base and account for water of
hydration where appropriate (e.g. morphine sulfate pentahydrate).
Cheers... Brian
Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Fisher Dennis
Sent: Wednesday, March 26, 2014 8:57 AM
To: [email protected]
Subject: [NMusers] Correcting for salt vs. base
Colleagues
I have been troubled by a minor issue for some time. Consider the following
situation:
Dose is reported in mg salt
Cp is reported in ng/ml base
Since CL is dose / AUC and AUC is merely the integral of Cp vs. time, in
theory, dose should be converted to mg base (or concentration to ng/ml salt).
However, I am not sure if everyone does that.
In fact, an argument against it is that not doing the conversion permits one to
relate the administered dose (which is usually based on salt) to a Cp value
(usually based on base).
I am interested to hear what approach people use.
Dennis
Dennis Fisher MD
P < (The "P Less Than" Company)
Phone: 1-866-PLessThan (1-866-753-7784)
Fax: 1-866-PLessThan (1-866-753-7784)
http://www.plessthan.com/